AB189513

Anti-NSG2 antibody [EPR15389(B)] - C-terminal

Name: Anti-NSG2 antibody [EPR15389(B)] - C-terminal (ab189513) | Abcam
Brand: Abcam Limited
SKU: AB189513
Rating: 5 (1 reviews)

RabMAb
Recombinant
각 태그의 뜻

(1 리뷰)

(7 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal NSG2 antibody. C-terminal. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 7 publications.

대체 명칭 보기

CALY3, NSG2, Neuronal vesicle trafficking-associated protein 2, Neuron-specific protein family member 2, Protein p19, Hmp19

2 이미지

Supplier Data

Western blot - Anti-NSG2 antibody [EPR15389(B)] - C-terminal (AB189513)

All lanes:

Western blot - Anti-NSG2 antibody [EPR15389(B)] - C-terminal (ab189513) at 1/1000 dilution

Lane 1:

SH-SY5Y cell lysate at 10 µg

Lane 2:

Rat brain lysate at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 19 kDa

false

Supplier Data

Western blot - Anti-NSG2 antibody [EPR15389(B)] - C-terminal (AB189513)

All lanes:

Western blot - Anti-NSG2 antibody [EPR15389(B)] - C-terminal (ab189513) at 1/1000 dilution

Lane 1:

Neuro-2a cell lysate at 20 µg

Lane 2:

Human fetal brain lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Predicted band size: 19 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR15389(B)

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NSG2 also known as Neuronal Vesicle Trafficking Associated 2 is a protein involved in intracellular processes. It has a molecular mass of approximately 49 kDa. NSG2 predominantly expresses in the brain particularly in neurons which suggests its critical role in neural activity. The protein localizes in synaptic vesicles hinting at its involvement in synaptic functions. Its expression is tightly regulated during neuronal development indicating its potential role in neural differentiation and maturation.

Biological function summary

The NSG2 protein contributes to vesicle trafficking within neuronal cells. It plays a part in a multiprotein complex that may regulate synaptic vesicle cycling or neurotransmitter release. The protein influences synaptic structure and function important for neural communication. Researchers have observed its significant impact on maintaining synaptic plasticity suggesting its role in learning and memory processes.

Pathways

NSG2 participates in neural development and synaptic communication pathways. It interacts within the neurotransmitter release cycle specifically affecting the synaptic vesicle cycle. In this context proteins such as SNAP-25 and synaptotagmin may have close interactions with NSG2 through these pathways. These interactions highlight the significance of NSG2 in neural circuit stability and function impacting neuronal transmission efficiency.

NSG2 has associations with neurological conditions including autism spectrum disorder and schizophrenia. Altered expression or mutation of NSG2 links it with these cognitive and developmental disorders. The protein's interactions with other targets like SNAP-25 and synaptotagmin might play a part in the manifestation or progression of these conditions. Understanding NSG2's role in these disorders could contribute to the development of therapeutic strategies.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information NSG2

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제품이 사용된 논문 (7)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular brain 17:95 PubMed39695712

2024

Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility.

Applications

Unspecified application

Species

Unspecified reactive species

Amber J Zimmerman,Antonio Serrano-Rodriguez,Melody Sun,Sandy J Wilson,David N Linsenbardt,Jonathan L Brigman,Jason P Weick

The Journal of biological chemistry 299:105446 PubMed37949230

2023

Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Malene Overby,Antonio Serrano-Rodriguez,Somayeh Dadras,Ann Kathrine Christiansen,Gözde Ozcelik,Stefan F Lichtenthaler,Jason Porter Weick,Heidi Kaastrup Müller

Genes, brain, and behavior 21:e12816 PubMed35577358

2022

Global loss of Neuron-specific gene 1 causes alterations in motor coordination, increased anxiety, and diurnal hyperactivity in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Roman Austin,Praveen Chander,Amber J Zimmerman,Malene Overby,Laura Digilio,Chan Choo Yap,David N Linsenbardt,Heidi Kaastrup Müller,Jason P Weick

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:4415-4434 PubMed35474277

2022

Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Chan Choo Yap,Laura Digilio,Lloyd P McMahon,Tuanlao Wang,Bettina Winckler

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 27:400-408 PubMed33478608

2021

Loss of Arf Guanine Nucleotide Exchange Factor GBF1 Activity Disturbs Organelle Dynamics in Mouse Oocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan-Jing Zou,Meng-Meng Shan,Zhen-Nan Pan,Meng-Hao Pan,Xiao-Han Li,Shao-Chen Sun

eNeuro 6: PubMed30680309

2019

Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission.

Applications

Unspecified application

Species

Unspecified reactive species

Praveen Chander,Matthew J Kennedy,Bettina Winckler,Jason P Weick

The Journal of comparative neurology 525:1861-1878 PubMed28299779

2017

The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Kelly Barford,Chan Choo Yap,Noelle D Dwyer,Bettina Winckler

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-NSG2 antibody [EPR15389(B)] - C-terminal

Western blot - Anti-NSG2 antibody [EPR15389(B)] - C-terminal (AB189513)

Western blot - Anti-NSG2 antibody [EPR15389(B)] - C-terminal (AB189513)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (7)

Product promise