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AB235924

Anti-NUBPL antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal NUBPL antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NUBPL.

대체 명칭 보기

C14orf127, NUBPL, Iron-sulfur cluster transfer protein NUBPL, IND1 homolog, Nucleotide-binding protein-like, huInd1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUBPL antibody (AB235924)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUBPL antibody (AB235924)

Paraffin-embedded human colon cancer tissue stained for NUBPL with ab235924 (1/100 dilution) in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUBPL antibody (AB235924)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUBPL antibody (AB235924)

Paraffin-embedded human liver cancer tissue stained for NUBPL with ab235924 (1/100 dilution) in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human NUBPL.

Q8TB37

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대체품

Primary Antibodies

AB229670

Anti-NUBPL antibody

Western blot - Anti-NUBPL antibody (AB229670)

  • 0
  • 0
Primary Antibodies

AB171741

Anti-NUBPL antibody [EPR11833]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NUBPL antibody [EPR11833] (AB171741)

  • 0
  • 0

보완 제품

Primary Antibodies

AB154060

Anti-ISCU antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ISCU antibody (AB154060)

  • 0
  • 0
Sample Prep & Detection Kits

AB110170

Mitochondria Isolation Kit for Cultured Cells

Western blot - Mitochondria Isolation Kit for Cultured Cells (AB110170)

  • 5
  • 2
Primary Antibodies

AB108257

Anti-ADX antibody [EPR4629]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-ADX antibody [EPR4629] (AB108257)

  • 5
  • 1
Primary Antibodies

AB310764

Alexa Fluor® 594 Anti-CD38 antibody [SP149] - C-terminal

RabMAb|Recombinant

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

NUBPL also known as nucleotide-binding protein-like and IND1 is a mitochondrial matrix protein with a molecular mass of approximately 34 kDa. It is expressed in various tissues being notably present in high-energy demand tissues like heart and skeletal muscle. Mechanically NUBPL plays a critical role in the assembly of complex I of the mitochondrial respiratory chain by aiding the incorporation of Fe-S clusters which are essential for catalytic activity.
Biological function summary

NUBPL functions as a chaperone-like protein ensuring proper assembly of complex I which is part of the mitochondrial respiratory chain. NUBPL operates as a component of the mitochondrial iron-sulfur (Fe-S) cluster assembly complex. It directly interacts with Fe-S protein synthesis an essential part of cellular respiration. The precise regulation of this complex facilitates energy production within cells by supporting efficient electron transport.

Pathways

NUBPL is integral to the mitochondrial oxidative phosphorylation pathway a process that generates ATP the main energy currency of cells. It associates with the iron-sulfur (Fe-S) cluster biogenesis pathway working alongside proteins such as ISCU and NFS1. These interactions ensure the effective transfer and stabilization of Fe-S clusters necessary for mitochondrial function and metabolic processes.

NUBPL mutations have been linked to mitochondrial complex I deficiency which can lead to a spectrum of neurodegenerative conditions including Leigh syndrome. The disease often involves interactions with proteins such as NDUFS4 another complex I assembly factor. Additionally possible links may exist between NUBPL dysfunction and mitochondrial diseases characterized by impaired energy production and accumulation of metabolic intermediates highlighting the protein's importance in maintaining cellular energy homeostasis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed : 19752196). May deliver one or more Fe-S clusters to complex I subunits (PubMed : 19752196).
See full target information NUBPL
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in immunology 15:1456649 PubMed39896807

2025

Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC.

Applications

Unspecified application

Species

Unspecified reactive species

Haotian Qin,Juan Xu,Yaohang Yue,Meiling Chen,Zheng Zhang,Panpan Xu,Yan Zheng,Hui Zeng,Jian Weng,Jun Yang,Fei Yu

Genes & development 38:738-754 PubMed39168636

2024

The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma.

Applications

Unspecified application

Species

Unspecified reactive species

Ying-Jiun C Chen,Govinal Badiger Bhaskara,Yue Lu,Kevin Lin,Sharon Y R Dent
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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