AB225940

Anti-Nucleoside-diphosphate kinase antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal Nucleoside-diphosphate kinase antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CMPK1 aa 1-200.

대체 명칭 보기

CMK, CMPK, UCK, UMK, UMPK, CMPK1, UMP-CMP kinase, Deoxycytidylate kinase, Nucleoside-diphosphate kinase, Uridine monophosphate/cytidine monophosphate kinase, CK, dCMP kinase, UMP/CMP kinase, UMP/CMPK

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nucleoside-diphosphate kinase antibody (AB225940)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nucleoside-diphosphate kinase antibody (AB225940)

Paraffin-embedded human colon cancer tissue stained for Nucleoside-diphosphate kinase using ab225940 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human CMPK1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P30085

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Nucleoside-diphosphate kinase (NDPK) also known as nucleoside-diphosphate kinase NM23 and NDP kinase mechanically catalyzes the exchange of phosphate groups between different nucleoside diphosphates and triphosphates. This protein weighs approximately 17 kDa and is expressed in various tissues including liver heart and brain. Its catalytic function relies on a ping-pong mechanism where a high-energy phosphoryl transfer occurs important for maintaining the balance of cellular nucleotide pools.

Biological function summary

Nucleoside-diphosphate kinase facilitates essential cellular processes by regulating the levels of nucleoside triphosphates key building blocks for nucleic acid synthesis. It is often found as part of a larger complex composed of hexameric structures in cells impacting cellular energy homeostasis and metabolism. The protein's role extends to involvement in cellular signaling differentiation and proliferation contributing to its importance in cellular regulation.

Pathways

The role of nucleoside-diphosphate kinase extends to critical biological pathways such as the nucleotide metabolism and cell signaling pathways where it ensures the equilibrium of nucleoside triphosphates used in DNA and RNA synthesis. NDPK interacts with other proteins particularly linking with kinases and phosphatases to perform its regulatory functions. This protein integrates closely with the MAPK signaling pathway influencing cellular responses to external stimuli and cellular growth.

Issues with nucleoside-diphosphate kinase have been linked to conditions such as cancer and neurodegenerative diseases. Mutations or aberrant expression of NDPK can impact its function leading to alterations in cellular processes that drive oncogenesis. For example its altered interaction with proteins like p53 in cancer can impair tumor suppressor functions facilitating tumorigenesis. Additionally its dysregulation has associations with neurodegenerative diseases where it may affect neuronal survival and function.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

See full target information CMPK1

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Diabetes, metabolic syndrome and obesity : targets and therapy 17:2923-2934 PubMed39104597

2024

Integrated Transcriptomics and Proteomics Identified CMPK1 as a Potential Biomarker for Type 2 Diabetes Mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Kang Zhao,Rui Mao,Wei Yi,Zhengyun Ren,Yanjun Liu,Huawu Yang,Senlin Wang,Zhonghui Feng

BioMed research international 2021:7463867 PubMed33981772

2021

Circular RNA circPVT1 Contributes to Doxorubicin (DXR) Resistance of Osteosarcoma Cells by Regulating TRIAP1 via miR-137.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Li,Yan Huang,Gang Wang

Frontiers in oncology 11:637470 PubMed33816278

2021

CMPK1 Regulated by miR-130b Attenuates Response to 5-FU Treatment in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Huaizhu Chu,Nahui Han,Jianguo Xu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nucleoside-diphosphate kinase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nucleoside-diphosphate kinase antibody (AB225940)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise