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AB204490

Anti-NUP188 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal NUP188 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NUP188 aa 250-400.

대체 명칭 보기

KIAA0169, NUP188, Nucleoporin NUP188, hNup188

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-NUP188 antibody (AB204490)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-NUP188 antibody (AB204490)

Immunofluorescent analysis of paraformaldehyde-fixed SiHa cells labeling NUP188 using ab204490 at 4 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUP188 antibody (AB204490)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUP188 antibody (AB204490)

Immunohistochemical analysis of paraffin-embedded Human endometrium tissue labeling NUP188 using ab204490 at a 1/20 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human NUP188 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q5SRE5

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보완 제품

Primary Antibodies

AB188413

Anti-Nucleoporin p62/NUP62 antibody [2A]

Immunocytochemistry/ Immunofluorescence - Anti-Nucleoporin p62/NUP62 antibody [2A] (AB188413)

  • 0
  • 0
Primary Antibodies

AB199528

Anti-NUP155 antibody [EPR17111]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NUP155 antibody [EPR17111] (AB199528)

  • 1
  • 1
Primary Antibodies

AB124980

Anti-NUP98 antibody [EPR6678] - Nuclear Pore Marker

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NUP98 antibody [EPR6678] - Nuclear Pore Marker (AB124980)

  • 5
  • 1
Primary Antibodies

AB24700

Anti-Nup153 antibody [QE5]

Immunocytochemistry/ Immunofluorescence - Anti-Nup153 antibody [QE5] (AB24700)

  • 4
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The NUP188 protein also known as nucleoporin 188 is a core component of the nuclear pore complex (NPC). It has a molecular mass of approximately 188 kDa. This protein is expressed in various tissues where it contributes to the structure and function of the NPC which is essential for the transport of molecules between the nucleus and cytoplasm. NUP188 interacts directly with other nucleoporins to form the intricate architecture of the NPC facilitating the regulation of nucleocytoplasmic exchange.
Biological function summary

NUP188 plays a critical role in maintaining the integrity of the nuclear envelope. It is an integral part of the nuclear pore complex joining together with other proteins to ensure the selective transport of macromolecules. NUP188 contributes to the regulation of gene expression and cell cycle progression by mediating nucleoplasmic communication. Its presence in the NPC structure ensures that the necessary components for DNA replication and repair can pass through the nuclear envelope.

Pathways

NUP188 is involved in important cellular transport pathways such as the nucleo-cytoplasmic transport pathway. This pathway includes other nucleoporins like NUP93 and NUP205 which work with NUP188 to facilitate the movement of proteins and RNA. The precise regulation of these pathways supports functions like RNA processing and ribosomal biogenesis ensuring proper cellular operation and survival.

Disruptions in NUP188 function have associations with cancer and neurodegenerative diseases. Altered expression or mutation of NUP188 can lead to changes in the nucleocytoplasmic transport mechanism potentially contributing to tumorigenesis or the progression of neurological conditions. Its interaction with other nucleoporins like NUP93 in these contexts highlights the potential for broad effects on cellular homeostasis making it significant in the study of related pathologies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed : 32275884).
See full target information NUP188
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in immunology 16:1586784 PubMed40861463

2025

The value of nucleoporin 188 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to gastric cancer verification.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengfeng Zhu,Ru Peng,Huanhuan Cai

Anatomical record (Hoboken, N.J. : 2007) 305:209-221 PubMed34041863

2021

Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain.

Applications

Unspecified application

Species

Unspecified reactive species

Sameh M Farouk,Ahmed M Abdellatif,Elsayed Metwally
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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