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AB129760

Anti-OB Cadherin antibody

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(1 출판물)

Rabbit Polyclonal OB Cadherin antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CDH11.

대체 명칭 보기

Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11

1 이미지
Western blot - Anti-OB Cadherin antibody (AB129760)
  • WB

Unknown

Western blot - Anti-OB Cadherin antibody (AB129760)

All lanes:

Western blot - Anti-OB Cadherin antibody (ab129760) at 1/500 dilution

Lane 1:

Jurkat cell extract

Lane 2:

Jurkat cell extract with synthesized peptide

Predicted band size: 23 kDa,87 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CDH11. The exact immunogen used to generate this antibody is proprietary information.

P55287

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대체품

Primary Antibodies

AB151302

Anti-OB Cadherin antibody

  • 4
  • 3
Primary Antibodies

AB151446

Anti-OB Cadherin antibody [16G5]

Western blot - Anti-OB Cadherin antibody [16G5] (AB151446)

  • 0
  • 0
Primary Antibodies

AB223087

Anti-OB Cadherin antibody

Immunocytochemistry/ Immunofluorescence - Anti-OB Cadherin antibody (AB223087)

  • 5
  • 1

보완 제품

Assay Kits

AB267594

Human OB Cadherin ELISA Kit

Sandwich ELISA - Human OB Cadherin ELISA Kit (AB267594)

  • 0
  • 0
Primary Antibodies

AB32572

Anti-beta Catenin antibody [E247] - ChIP Grade

BOND RX™ Validated|Advanced Validation|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Catenin antibody [E247] - ChIP Grade (AB32572)

  • 5
  • 75
Primary Antibodies

AB282457

Anti-EpCAM antibody [RM1016]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry - Anti-EpCAM antibody [RM1016] (AB282457)

  • 3
  • 1
Primary Antibodies

AB52866

Anti-alpha Tubulin antibody [EP1332Y] - Loading Control

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-alpha Tubulin antibody [EP1332Y] - Loading Control (AB52866)

  • 5
  • 31
Primary Antibodies

AB51034

Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker (AB51034)

  • 5
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab129760 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
보관 버퍼
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

OB Cadherin is a calcium-dependent cell adhesion molecule also known as Cadherin-11. It has a mass of about 120 kDa. OB Cadherin is expressed widely in mesenchymal tissues including osteoblasts fibroblasts and synovial tissues. This cadherin plays a role in the regulation of cell-cell adhesion influencing the mechanical structure and integrity of tissues. Its expression in differentiated cells indicates its involvement in tissue maintenance and repair. OB Cadherin is also contributing to the segregation of different cell types during developmental processes.
Biological function summary

OB Cadherin plays an important role in tissue morphogenesis and remodeling. It is a part of the adherens junction complex which also includes catenins. This complex mediates cell contact and communication essential for structural integrity and signaling. OB Cadherin supports the proper organization and separation of cells within tissues impacting processes like bone development and wound healing. It acts as a mediator in mechanical signaling influencing cellular responses to mechanical stress.

Pathways

OB Cadherin participates in signaling pathways involved in cell adhesion and migration notably in the Wnt and BMP pathways. These pathways are essential for developmental processes and maintain tissue homeostasis. OB Cadherin interacts closely with proteins like beta-catenin playing a role in transcriptional regulation that influences cell fate decisions. Its function in these pathways demonstrates its critical role in regulating cellular activities tied to growth and differentiation.

OB Cadherin is linked to conditions like rheumatoid arthritis and cancer metastasis. In rheumatoid arthritis overexpression of OB Cadherin in synovial tissues can contribute to joint inflammation and tissue destruction associated with interactions with fibroblast-like synoviocytes. In cancer metastasis OB Cadherin's role in cell adhesion and migration highlights its potential influence in the spread of cancer cells often in relation to altered interactions with proteins like N-cadherin. These associations make OB Cadherin an important target for research into disease mechanisms and therapies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed : 33811546). Involved in the regulation of cell migration (PubMed : 33811546).
See full target information CDH11
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

American journal of translational research 16:3922-3937 PubMed39262709

2024

The Cdc42/Rac1 pathway: a molecular mechanism behind iron-deficiency-driven aortic medial degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Su Wang,Hengjuan Liu,Junxia Hu,Ting Li,Bowen Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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