AB110647

Anti-OCM2 antibody [EPR5310]

RabMAb
Recombinant
각 태그의 뜻

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Rabbit Recombinant Monoclonal OCM2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.

대체 명칭 보기

OCMN, OCM2, Oncomodulin-2

2 이미지

Unknown

Western blot - Anti-OCM2 antibody [EPR5310] (AB110647)

All lanes:

Western blot - Anti-OCM2 antibody [EPR5310] (ab110647) at 1/1000 dilution

Lane 1:

Human placenta lysate at 10 µg

Lane 2:

Mouse heart lysate at 10 µg

Lane 3:

Rat heart lysate at 10 µg

Lane 4:

Fetal heart lysate at 10 µg

Lane 5:

Mouse kidney lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 12 kDa

Observed band size: 12 kDa

false

OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647)

OI-RD Scanning

Unknown

OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647)

We have systematically measured KD (the equilibrium dissociation constant between the antibody and its antigen), of more than 840 recombinant antibodies to assess not only their individual KD values but also to see the average affinity of antibody. Based on the comparison with published literature values for mouse monoclonal antibodies, Recombinant antibodies appear to be on average 1-2 order of magnitude higher affinity.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR5310

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

OCM2 also known as Oncomodulin 2 is a calcium-binding protein with a molecular mass of approximately 12 kDa. It belongs to the family of EF-hand proteins and is part of the wider calmodulin group. OCM2 shows expression mainly in the retina and cochlea indicating its role in sensory functions. This protein is essential for calcium ion homeostasis requiring accurate localization to exert its functions in physiological conditions.

Biological function summary

Oncomodulin 2 plays a role in regulating intracellular calcium levels which affects various cellular processes. It does not appear to function as part of a known complex. Its expression in sensory areas like the retina and cochlea suggests involvement in signal transduction pathways related to visual and auditory functions. By modulating calcium ions OCM2 supports neuronal specificity and survival indicating a potential role in the development and maintenance of sensory tissues.

Pathways

OCM2 contributes to calcium signaling pathways that are important for cellular communication and regulation. It interacts with proteins such as calmodulin and troponin C which are integral to calcium signal transduction. These pathways relay messages important for cellular adaptation to environmental changes and for the maintenance of cellular homeostasis. The protein's ability to bind calcium supports mechanistic activities within these pathways.

Variations or dysfunction of OCM2 associate with sensory impairments such as retinal degeneration and certain forms of hearing loss. Studies indicate a connection to proteins like Nrl and Myo7a within these conditions. Such associations highlight the potential for OCM2 as a biomarker or therapeutic target in treating sensory-related disorders. The disease links reinforce the understanding of OCM2’s role in sensory organ function and pathogenesis.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information OCM2

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature 506:445-50 PubMed24553142

2014

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

Applications

Unspecified application

Species

Unspecified reactive species

S C Mack,H Witt,R M Piro,L Gu,S Zuyderduyn,A M Stütz,X Wang,M Gallo,L Garzia,K Zayne,X Zhang,V Ramaswamy,N Jäger,D T W Jones,M Sill,T J Pugh,M Ryzhova,K M Wani,D J H Shih,R Head,M Remke,S D Bailey,T Zichner,C C Faria,M Barszczyk,S Stark,H Seker-Cin,S Hutter,P Johann,S Bender,V Hovestadt,T Tzaridis,A M Dubuc,P A Northcott,J Peacock,K C Bertrand,S Agnihotri,F M G Cavalli,I Clarke,K Nethery-Brokx,C L Creasy,S K Verma,J Koster,X Wu,Y Yao,T Milde,P Sin-Chan,J Zuccaro,L Lau,S Pereira,P Castelo-Branco,M Hirst,M A Marra,S S Roberts,D Fults,L Massimi,Y J Cho,T Van Meter,W Grajkowska,B Lach,A E Kulozik,A von Deimling,O Witt,S W Scherer,X Fan,K M Muraszko,M Kool,S L Pomeroy,N Gupta,J Phillips,A Huang,U Tabori,C Hawkins,D Malkin,P N Kongkham,W A Weiss,N Jabado,J T Rutka,E Bouffet,J O Korbel,M Lupien,K D Aldape,G D Bader,R Eils,P Lichter,P B Dirks,S M Pfister,A Korshunov,M D Taylor

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-OCM2 antibody [EPR5310]

Western blot - Anti-OCM2 antibody [EPR5310] (AB110647)

OI-RD Scanning - Anti-OCM2 antibody [EPR5310] (AB110647)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise