Mouse Monoclonal Oct-2 antibody. Suitable for IHC-P, WB, Protein Array and reacts with Human, Recombinant fragment, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human POU2F2 aa 100-300.
대체 명칭 보기
OCT2, OTF2, POU2F2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding protein 2, Octamer-binding transcription factor 2, Oct-2, OTF-2
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oct-2 antibody [OCT2/2137] (AB236558)
Formalin-fixed, paraffin-embedded human lymph node tissue stained for Oct-2 using ab236558 at 2 μg/ml in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oct-2 antibody [OCT2/2137] (AB236558)
Formalin-fixed, paraffin-embedded human tonsil tissue stained for Oct-2 using ab236558 at 2 μg/ml in immunohistochemical analysis.
- Protein Array
Unknown
Protein Array - Anti-Oct-2 antibody [OCT2/2137] (AB236558)
ab236558 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
- WB
Supplier Data
Western blot - Anti-Oct-2 antibody [OCT2/2137] (AB236558)
All lanes:
Western blot - Anti-Oct-2 antibody [OCT2/2137] (ab236558) at 2 µg/mL
All lanes:
Ramos (human Burkitt's lymphoma cell line) cell lysate
Predicted band size: 51 kDa
false
- WB
Supplier Data
Western blot - Anti-Oct-2 antibody [OCT2/2137] (AB236558)
All lanes:
Western blot - Anti-Oct-2 antibody [OCT2/2137] (ab236558) at 2 µg/mL
Lane 1:
Recombinant Oct-2 protein
Lane 2:
Daudi (human Burkitt's lymphoma cell line) cell lysate
Predicted band size: 51 kDa
false
Reactivity 정보
특성 및 보관 정보
제형
Purification 테크닉
Purification 관련 사항
보관 버퍼
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Oct-2 regulates the expression of target genes by binding to octamer motifs within promoters and enhancers. In the immune system Oct-2 plays a significant role in B cell differentiation and maturation. It acts as an essential transcriptional regulator of immunoglobulin gene expression. In neural tissues Oct-2 influences genes involved in neural differentiation and development. Oct-2 often does not act alone; it forms part of multi-protein complexes interacting with coactivators and corepressors to modulate gene expression tightly.
Pathways
Oct-2 participates in critical transcriptional regulatory networks. It is important in the immune response pathway controlling genes involved in B cell activation and antibody production. Oct-2 also interacts with Oct-1 another member of the POU family in controlling gene expression patterns related to adaptive immunity. Additionally Oct-2 influences pathways involved in neural development working alongside transcription factors like Pax-5 to regulate genes critical for the growth and differentiation of neuronal cells.
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타겟 정보
제품이 사용된 논문 (1)
Recent publications for all applications. Explore the 전체 목록 and refine your search
Medicine 100:e25028 PubMed33761659
2021
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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