JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB100928

Anti-OGDHL antibody

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal OGDHL antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OGDHL aa 400 to C-terminus.

대체 명칭 보기

KIAA1290, OGDHL, 2-oxoglutarate dehydrogenase complex component E1-like, Alpha-ketoglutarate dehydrogenase-like, OGDC-E1-like

1 이미지
Western blot - Anti-OGDHL antibody (AB100928)
  • WB

Unknown

Western blot - Anti-OGDHL antibody (AB100928)

All lanes:

Western blot - Anti-OGDHL antibody (ab100928) at 1/1000 dilution

Lane 1:

Human fetal liver lysate

Lane 2:

HepG2 cell lysate

Predicted band size: 114 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human OGDHL aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9ULD0

style
left-column

보완 제품

Primary Antibodies

AB307369

Anti-OGDH antibody [EPR27181-78]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OGDH antibody [EPR27181-78] (AB307369)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 2
Primary Antibodies

AB179452

Anti-ZNFX1 antibody [EPR12330]

RabMAb|Recombinant

Western blot - Anti-ZNFX1 antibody [EPR12330] (AB179452)

  • 0
  • 0
Primary Antibodies

AB263899

Anti-NLRP3 antibody [EPR23094-1]

KO Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-NLRP3 antibody [EPR23094-1] (AB263899)

  • 4
  • 2
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

OGDHL also known as Oxoglutarate Dehydrogenase-Like protein plays a significant role in the mitochondrial matrix where it is a part of the alpha-ketoglutarate dehydrogenase complex. This enzyme with a molecular mass of approximately 116 kDa catalyzes the conversion of alpha-ketoglutarate into succinyl-CoA and carbon dioxide. It predominantly expresses in tissues with high metabolic activity such as the brain heart and skeletal muscle where efficient energy production is critical.
Biological function summary

OGDHL facilitates the regulation of the tricarboxylic acid (TCA) cycle an essential component of cellular respiration. It forms a part of a multi-enzyme complex that ensures the continuation of the TCA cycle by contributing to the oxidation of carbohydrates and the generation of energy. The activity of OGDHL directly affects the flux of the cycle impacting cellular metabolic rates and bioenergetics significantly. The integrity and functionality of this complex are important for maintaining energy homeostasis within cells.

Pathways

OGDHL is deeply entwined with the metabolic processes of the TCA cycle and the electron transport chain. Through the TCA cycle it associates with essential respiratory enzymes contributing to ATP production. Moreover its function closely aligns with proteins such as NADH-dehydrogenase which plays a critical role in facilitating electron transfer and oxidative phosphorylation. This connection is vital for sustaining cellular energy needs and for adapting to changing metabolic demands.

Dysregulation of OGDHL activity links to metabolic disorders and neurodegenerative diseases. Deficiencies or malfunctions in OGDHL have associations with conditions such as Leigh syndrome a severe neurological disorder and Alzheimer's disease where energy metabolism is disrupted. In these cases interactions with proteins like amyloid precursor protein and tau become significant as they are often involved in the pathophysiology of such conditions further emphasising OGDHL's importance in maintaining neuronal health and metabolic stability.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (By similarity). The OGDHC complex is mainly active in the mitochondrion (By similarity). Involved in the inhibition of cell proliferation and in apoptosis (PubMed : 23152800, PubMed : 31175094).
See full target information OGDHL
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in cardiovascular medicine 9:741920 PubMed35463769

2022

The Potential of Metabolism-Related Gene OGDHL as a Biomarker for Myocardial Remodeling in Dilated Cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Yaohan Tang,Yaoxi Zhu,Yang Lu,Hongmin Yang,Han Yang,Lixia Li,Changhu Liu,Yimei Du,Jing Yuan

PloS one 7:e48770 PubMed23152800

2012

OGDHL is a modifier of AKT-dependent signaling and NF-κB function.

Applications

Unspecified application

Species

Unspecified reactive species

Tanusree Sen,Nilkantha Sen,Maartje G Noordhuis,Rajani Ravi,T-C Wu,Patrick K Ha,David Sidransky,Mohammad Obaidul Hoque
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com