AB254043

Anti-Olig2 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal Olig2 antibody. Suitable for WB, ICC/IF and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Olig2.

대체 명칭 보기

BHLHB, Basic domain helix loop helix protein class B 1, Basic helix loop helix protein class B 1, Class B basic helix-loop-helix protein 1, Class E basic helix-loop-helix protein 19, Human protein kinase C binding protein RACK17, OLIG2_HUMAN, OTTHUMP00000067569, OTTHUMP00000067570, Oligo2, Oligodendrocyte lineage transcription factor 2, Oligodendrocyte specific bHLH transcription factor 2, Oligodendrocyte transcription factor 2, PRKCBP2, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, bHLHB1, bHLHe19

1 이미지

Immunocytochemistry/ Immunofluorescence - Anti-Olig2 antibody (AB254043)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Olig2 antibody (AB254043)

Rat primary cortical neuroepithelial cells labeling Olig2 using ab254043 (red) at a 1/1000 dilution in ICC/IF. The cells were treated with basic FGF for 30 hrs prior to staining (this induces Olig2 expression in these primary cells).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Mouse Olig2. The exact immunogen used to generate this antibody is proprietary information.

Q9EQW6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/1000", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 8 Constituents: 2.42% Tris, 0.75% Glycine

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Olig2 also known as Oligo2 or OLIG2 is a protein with a molecular mass of around 32 kDa. It belongs to the basic helix-loop-helix (bHLH) family of transcription factors which play roles in neurodevelopment. Olig2 is expressed mainly in the central nervous system particularly in oligodendrocyte progenitor cells and motor neuron progenitors. As an important marker Olig2 staining is often used in studies involving these cell types to understand differentiation processes.

Biological function summary

Olig2 regulates gene expression important for the proper development of the central nervous system. It functions both independently and as a part of transcriptional complexes to influence the fate of neural progenitors. In particular its presence decides whether these progenitors will differentiate into neurons astrocytes or oligodendrocytes. Among the proteins it interacts with are factors that modulate neurogenesis and myelination highlighting its importance in maintaining normal brain homeostasis.

Pathways

Olig2 plays an important role in the oligodendrocyte differentiation and motor neuron generation pathways. It works closely with proteins such as SOX10 and NKX2.2 to regulate oligodendrocyte maturation. In the motor neuron pathway Olig2 interacts with proteins like NKX6.1 and LHX3 coordinating the development of motor neurons. These pathways demonstrate Olig2's function as a critical transcription factor influencing neural development and plasticity.

Abnormalities in Olig2 expression or function relate to conditions such as gliomas and Multiple Sclerosis (MS). Elevated levels of Olig2 are often seen in gliomas where it might cooperate with proteins like IDH1 to drive tumor growth. In MS the impairment of oligodendrocyte function can link back to disruptions in normal Olig2 activity or expression. These associations make Olig2 a significant target for potential therapeutic interventions in neurological conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information Olig2

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular therapy. Nucleic acids 35:102282 PubMed39176174

2024

Suppression of HSV-1 infection and viral reactivation by CRISPR-Cas9 gene editing in 2D and 3D culture models.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Bellizzi,Senem Çakır,Martina Donadoni,Rahsan Sariyer,Shuren Liao,Hong Liu,Guo-Xiang Ruan,Jennifer Gordon,Kamel Khalili,Ilker K Sariyer

Journal of neurovirology 30:362-379 PubMed38600307

2024

Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Donadoni,Senem Cakir,Anna Bellizzi,Michael Swingler,Ilker K Sariyer

International journal of molecular sciences 22: PubMed33498219

2021

MST3 Involvement in Na and K Homeostasis with Increasing Dietary Potassium Intake.

Applications

Unspecified application

Species

Unspecified reactive species

Chee-Hong Chan,Sheng-Nan Wu,Bo-Ying Bao,Houng-Wei Li,Te-Ling Lu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Olig2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Olig2 antibody (AB254043)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise