Anti-OPN3 antibody

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G protein-coupled receptor which selectively activates G(i/o) proteins via ultraviolet A (UVA) light-mediated activation in the skin, thereby decreasing cellular cAMP (PubMed : 28842328, PubMed : 31380578). Binds both 11-cis retinal and all-trans retinal (PubMed : 31097585). Regulates melanogenesis in melanocytes by specifically inhibiting MC1R-evoked cAMP signaling, modulating calcium flux, regulating CAMK2 phosphorylation, and subsequently phosphorylating CREB, p38, ERK and MITF, probably in a constitutive, light-independent manner (PubMed : 28842328, PubMed : 31097585). In the paraventricular nucleus of the hypothalamus, inhibits MC4R-mediated cAMP signaling and activates KCNJ13 channel opening in a constitutive manner, thereby promoting food intake and modulating spontaneous firing of neurons (PubMed : 39951488). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed : 31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed : 31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed : 28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed : 30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed : 31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity).

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ECPN, OPN3, Opsin-3, Encephalopsin, Panopsin