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AB88686

Anti-ORC6L antibody

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Mouse Polyclonal ORC6L antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ORC6.
3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-ORC6L antibody (AB88686)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ORC6L antibody (AB88686)

ab88686 at 10 μg/ml detecting ORC6L in paraformaldehyde fixed, permeabilised HeLa cells by immunofluorescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ORC6L antibody (AB88686)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ORC6L antibody (AB88686)

ab88686 at 3 μg/ml detecting ORC6L in formalin-fixed paraffin-embedded Human placenta by immunohistochemistry.

Western blot - Anti-ORC6L antibody (AB88686)
  • WB

Unknown

Western blot - Anti-ORC6L antibody (AB88686)

All lanes:

Western blot - Anti-ORC6L antibody (ab88686) at 1 µg/mL

All lanes:

Human pancreas tissue lysate at 50 µg

Predicted band size: 28 kDa

Observed band size: 28 kDa

false

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ORC6.

Q9Y5N6

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보완 제품

Primary Antibodies

AB251776

Anti-ORC1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ORC1 antibody (AB251776)

  • 4
  • 1
Primary Antibodies

AB202067

Anti-CDT1/DUP antibody [EPR17891]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CDT1/DUP antibody [EPR17891] (AB202067)

  • 5
  • 3
Primary Antibodies

AB188423

Anti-Cdc6 antibody - N-terminal

Immunocytochemistry/ Immunofluorescence - Anti-Cdc6 antibody - N-terminal (AB188423)

  • 5
  • 2
Primary Antibodies

AB88691

Anti-NPRL2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-NPRL2 antibody (AB88691)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3 µg/mL", "IHCP-species-notes": "<p></p> Antigen retrieval is not essential but may optimise staining.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ORC6L also known as Origin Recognition Complex Subunit 6 is a protein that plays a mechanical role in the initiation of DNA replication. It weighs approximately 30 kDa and localizes in the nucleoplasm of cells. ORC6L is expressed in various tissues with higher expression observed in testis pancreas and thymus. It is an important component ensuring the proper functioning and regulation of DNA replication origins.
Biological function summary

DNA replication relies on ORC6L as part of the origin recognition complex (ORC) a multi-protein assembly essential for marking the origins of replication. The ORC complex of which ORC6L is a vital member initiates the assembly of pre-replicative complexes important for cell cycle progression. By binding to specific DNA sites ORC6L helps recruit other initiation factors ensuring that DNA replication occurs only once per cell cycle maintaining genomic stability.

Pathways

Different phases of the cell cycle require ORC6L's role in the DNA replication pathway. This protein's function connects with other components of the ORC such as ORC1 ORC2 and ORC3 to control replication initiation. Furthermore ORC6L interacts with proteins such as CDC6 and MCM integrating into the DNA replication licensing pathway which ensures the cell's readiness for DNA synthesis and subsequent divisions.

Mutations or dysregulation of ORC6L have implications for genomic instability and diseases like Meier-Gorlin syndrome. This condition characterized by growth retardation and skeletal anomalies often links to other ORC components including ORC1 and ORC4 illustrating its involvement in developmental abnormalities. Additionally cancer research indicates the possible connection between ORC6L dysfunction and tumorigenesis due to unchecked cell proliferation emphasizing its importance in maintaining a balanced cell division process.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
See full target information ORC6

대체 명칭 보기

ORC6L, ORC6, Origin recognition complex subunit 6
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death & disease 9:1035 PubMed30305611

2018

Demethylzeylasteral inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Kui Zhang,Gang Fu,Guangzhao Pan,Chongyang Li,Li Shen,Renjian Hu,Shunqin Zhu,Yibiao Chen,Hongjuan Cui
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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