Anti-Ornithine Carbamoyltransferase/OTC antibody [CL4046]
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Mouse Monoclonal Ornithine Carbamoyltransferase/OTC antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Ornithine transcarbamylase, mitochondrial aa 150-300.
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OTCase, OTC
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Carbamoyltransferase/OTC antibody [CL4046] (AB262865)
Paraffin-embedded human small intestine tissue stained for Ornithine Carbamoyltransferase/OTC using ab262865 at 1/5000 dilution in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Carbamoyltransferase/OTC antibody [CL4046] (AB262865)
Paraffin-embedded human endometrium tissue stained for Ornithine Carbamoyltransferase/OTC using ab262865 at 1/5000 dilution in immunohistochemical analysis. No expression, as expected.
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-Ornithine Carbamoyltransferase/OTC antibody [CL4046] (AB262865)
PFA-fixed, Triton X-100 permeabilized RH-30 cells stained for Ornithine Carbamoyltransferase/OTC (green) using ab262865 at 4 μg/ml in ICC/IF.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Carbamoyltransferase/OTC antibody [CL4046] (AB262865)
Paraffin-embedded human liver tissue stained for Ornithine Carbamoyltransferase/OTC using ab262865 at 1/5000 dilution in immunohistochemical analysis.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ornithine Carbamoyltransferase/OTC antibody [CL4046] (AB262865)
Paraffin-embedded human duodenum tissue stained for Ornithine Carbamoyltransferase/OTC using ab262865 at 1/5000 dilution in immunohistochemical analysis.
Reactivity 정보
특성 및 보관 정보
제형
Purification 테크닉
보관 버퍼
배송 시 보관 조건
적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Ornithine carbamoyltransferase plays a significant role in detoxifying ammonia by forming citrulline an important urea cycle intermediate. The protein functions as a homotrimer meaning three identical subunits form an active enzyme complex. This multimeric state facilitates efficient substrate processing allowing effective handling of nitrogen waste. The integral role of OTC in the urea cycle highlights its importance in maintaining systemic nitrogen balance.
Pathways
OTC is a central component of the urea cycle and influences nitrogen metabolism pathways. These pathways include the conversion of ammonia to urea an important detoxifying process for safe excretion by the kidneys. OTC closely interacts with enzymes such as argininosuccinate synthetase highlighting the coordinated action required to advance urea formation. Understanding OTC's participation within these pathways helps identify its regulatory points and the potential impact of genetic variations.
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