AB235298

Anti-ORP2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal ORP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human OSBPL2 aa 250-500.

대체 명칭 보기

KIAA0772, ORP2, OSBPL2, Oxysterol-binding protein-related protein 2, ORP-2, OSBP-related protein 2

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ORP2 antibody (AB235298)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ORP2 antibody (AB235298)

Paraffin-embedded human tonsil tissue stained for ORP2 using ab235298 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human OSBPL2 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.

Q9H1P3

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ORP2 also known as Oxysterol-binding protein-related protein 2 is a lipid-binding protein involved in intracellular lipid transport and signaling. The mass of ORP2 is approximately 55 kDa. This protein is mainly expressed in tissues with high metabolic activity such as the liver brain and adipose tissue. ORP2 binds to oxysterols and phosphoinositides recognizing specific lipid ligands an important characteristic of its functional role in cells.

Biological function summary

ORP2 regulates lipid metabolism and homeostasis through its lipid-binding abilities. It participates in the control of lipid flux between cellular compartments impacting membranes' composition and signaling processes. Evidence suggests ORP2 may not function as part of large complexes but rather acts independently or in small groups with other lipid transport proteins. ORP2's function in lipid regulation supports cellular events like cholesterol transport and modulation of membrane microdomain organization.

Pathways

ORP2 plays a role in the lipid signaling and metabolic pathways. A significant function includes its participation in the sterol regulatory element-binding proteins (SREBPs) pathway vital for cholesterol metabolism. ORP2 influences the balance of lipid composition by interacting with proteins like OSBP and other ORP family members impacting cellular lipid environments and homeostasis.

Altered ORP2 function associates with metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and atherosclerosis conditions where lipid metabolism is disrupted. Studies show links to insulin resistance and other metabolic syndromes suggesting ORP2 might contribute to disease progression through disturbed lipid signaling. Researchers are exploring these connections including interactions with proteins involved in lipid signaling like ABCA1 in relation to the development and therapeutic targeting of these disorders.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed : 30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed : 30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed : 11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed : 17428193, PubMed : 19224871, PubMed : 30581148).

See full target information OSBPL2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Aging 16:13132-13144 PubMed39475791

2024

OSBPL2 inhibition leads to apoptosis of cochlea hair cells in age-related hearing loss by inhibiting the AKT/FOXG1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Meina Li-Yang,Chao Ma,Xiaoye Wang,Jianqiang You

Frontiers in cardiovascular medicine 11:1319164 PubMed38545339

2024

The gene variant governs passive ascending aortic mechanics in the mgΔ mouse model of Marfan syndrome when superimposed to perlecan haploinsufficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Samar A Tarraf,Rodrigo Barbosa de Souza,Ashley Herrick,Lygia V Pereira,Chiara Bellini

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ORP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ORP2 antibody (AB235298)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise