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AB220143

Anti-OSBPL5/ORP5 antibody

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(1 출판물)

Rabbit Polyclonal OSBPL5/ORP5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human OSBPL5 aa 250 to C-terminus.

대체 명칭 보기

KIAA1534, OBPH1, ORP5, OSBPL5, Oxysterol-binding protein-related protein 5, ORP-5, OSBP-related protein 5, Oxysterol-binding protein homolog 1

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-OSBPL5/ORP5 antibody (AB220143)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-OSBPL5/ORP5 antibody (AB220143)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized HeLa cells labeling OSBPL5/ORP5 with ab220143 at 4 μg/ml (green).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human OSBPL5 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H0X9

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대체품

Primary Antibodies

AB59016

Anti-OSBPL5/ORP5 antibody

Flow Cytometry - Anti-OSBPL5/ORP5 antibody (AB59016)

  • 1
  • 1
Primary Antibodies

AB127171

Anti-OSBPL5/ORP5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OSBPL5/ORP5 antibody (AB127171)

  • 0
  • 0

보완 제품

Primary Antibodies

AB246987

Anti-SAMM50/SAM50 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SAMM50/SAM50 antibody (AB246987)

  • 0
  • 0
Primary Antibodies

AB228990

Anti-ORP8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ORP8 antibody (AB228990)

  • 0
  • 0
Primary Antibodies

AB109110

Anti-EEA1 antibody [EPR4245] - Early Endosome Marker

20ul selling size|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-EEA1 antibody [EPR4245] - Early Endosome Marker (AB109110)

  • 5
  • 4
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

OSBPL5 also known as ORP5 is a member of the oxysterol-binding protein (OSBP) family. This protein weighs approximately 99 kDa and is expressed in various tissues including the liver and the brain. OSBPL5 functions primarily as a lipid transfer protein playing a mechanical role in maintaining lipid homeostasis at membrane contact sites. It facilitates the transfer of phosphatidylserine and phosphatidylinositol-4-phosphate between membranes which is essential for cellular lipid regulation.
Biological function summary

The OSBP-like protein OSBPL5 is involved in cellular processes such as membrane trafficking and signal transduction. OSBPL5 is a part of the larger OSBP-related protein complex which regulates lipid interactions and distribution in cells. It influences vesicular transport and is implicated in the modulation of signaling pathways that govern cell growth and development.

Pathways

OSBPL5 functions in the phosphoinositide signaling and lipid metabolic pathways. It plays an important role in the transfer of lipids between the endoplasmic reticulum and other organelles impacting the regulation of phosphatidylinositol at the plasma membrane. OSBPL5 interacts with proteins like PI4KIIIα to regulate these processes. This interaction is important for maintaining cellular lipid dynamics necessary for various physiological functions.

OSBPL5's lipid transfer function associates with metabolic disorders like non-alcoholic fatty liver disease (NAFLD). Disruptions in lipid homeostasis by OSBPL5 can lead to excessive lipid accumulation in liver cells. Additionally OSBPL5 may have implications in neurological disorders given its expression in the brain alongside proteins such as APP that are involved in similar pathways. Understanding its role could provide insights into these diseases potentially aiding in therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane : specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed : 23934110, PubMed : 26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed : 21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed : 17428193).
See full target information OSBPL5
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports. Medicine 5:101572 PubMed38754420

2024

CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin Caulier,Sandy Joaquina,Pascal Gelebart,Tara Helén Dowling,Fatemeh Kaveh,Moritz Thomas,Luka Tandaric,Patrik Wernhoff,Niveditha Umesh Katyayini,Cara Wogsland,May Eriksen Gjerstad,Yngvar Fløisand,Gunnar Kvalheim,Carsten Marr,Sebastian Kobold,Jorrit M Enserink,Bjørn Tore Gjertsen,Emmet McCormack,Else Marit Inderberg,Sébastien Wälchli
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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