Anti-Osteopontin antibody
Anti-Osteopontin 항체
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(21 제품이 사용된 논문 )
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CiteAb
Western blot - Anti-Osteopontin antibody (AB11503)
Osteopontin western blotting using Anti-Osteopontin antibody ab11503. Publication image and figure legend from Liu, C., Ge, X., Chen, S., et al., 2015, Int J Mol Sci, PubMed 26703570.
Evodiamine inhibits the expression of migration-associated regulators. (A) VSMCs were pretreated with evodiamine for 6 h and then stimulated with PDGF-BB for another 24 h. Western blot was used to measure the protein expression levels of regulators involved in the VSMC migration, including matrix metalloproteinase (MMP)-2, MMP-9, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and osteopontin (OPN). For both MMP-2 and MMP-9, their latent forms (72 and 92 kDa, respectively) were detected.
false
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Osteopontin affects cell adhesion migration and survival. It does not form part of a known large complex but interacts closely with its integrin receptors. Osteopontin modulates immune responses and aids in bone remodeling by affecting osteoclast and osteoblast functions. It is also influential in inflammation processes where it orchestrates the recruitment and activation of macrophages. The osteopontin function is significant in both physiological processes and pathologies marking it as an important protein to study in numerous biological contexts.
Pathways
Osteopontin is integral to both the bone remodeling and immune response pathways. It collaborates with proteins like osteocalcin and matrix metalloproteinases within these processes. In the bone remodeling pathway osteopontin mediates communication between osteoclasts and osteoblasts impacting bone resorption and formation. In the immune response pathway it coordinates with cytokines such as interleukin-6 to modulate immune cell activities. Its roles in these pathways indicate its multifunctional nature and its impact across different biological systems.
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제품이 사용된 논문 (21)
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Cells 12: PubMed36980197
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Signal transduction and targeted therapy 8:41 PubMed36681678
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Histology and histopathology 38:1219-1229 PubMed36633331
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American journal of translational research 14:7726-7743 PubMed36505285
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Molecular medicine (Cambridge, Mass.) 28:121 PubMed36192693
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