JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB228508

Anti-Oxytocin-neurophysin 1 antibody

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Guinea pig Polyclonal Oxytocin-neurophysin 1 antibody. Suitable for IHC-Fr and reacts with Sheep samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human OXT aa 1-50.

대체 명칭 보기

OT, OXT, Oxytocin-neurophysin 1, OT-NPI, MGC126890, MGC126892, Neurophysin 1, Neurophysin I, OT, OT NPI, OXT, Ocytocin, Oxytocin Neurophysin preproprotein, Oxytocin prepro (neurophysin I), Oxytocin prepropeptide

1 이미지
Immunohistochemistry (Frozen sections) - Anti-Oxytocin-neurophysin 1 antibody (AB228508)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-Oxytocin-neurophysin 1 antibody (AB228508)

Frozen section of sheep hypothalamus tissue stained for Oxytocin-neurophysin 1 using ab228508 at 1/1000 dilution in immunohistochemical analysis, followed by a biotinylated secondary antibody.

주요 정보

Host species

Guinea pig

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Sheep

Applications

IHC-Fr

applications

Immunogen

Synthetic Peptide within Human OXT aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P01178

style
left-column

대체품

Primary Antibodies

AB124771

Anti-Oxytocin-neurophysin 1 antibody [EPR4665]

RabMAb|Recombinant

ELISA - Anti-Oxytocin-neurophysin 1 antibody [EPR4665] (AB124771)

  • 0
  • 0

보완 제품

Assay Kits

AB242248

Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit

Recombinant|SimpleStep

ELISA - Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit (AB242248)

  • 0
  • 0
Primary Antibodies

AB302667

Anti-c-Fos antibody [N486/32]

BOND RX™ Validated|Recombinant|Lab Essentials|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Fos antibody [N486/32] (AB302667)

  • 0
  • 0
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB213708

Anti-Vasopressin antibody [EPR20602]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Vasopressin antibody [EPR20602] (AB213708)

  • 0
  • 0
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 75
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Horse": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Pig": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rabbit": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Sheep": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Lyophilized
Reconstitution
reconstitute with water at 50µL
Purity
Whole antiserum
보관 버퍼
pH: 7 - 7.4
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Oxytocin-neurophysin 1 also known as prepro-oxytocin-neurophysin I is a precursor protein with a molecular weight of approximately 20 kDa. This protein is expressed primarily in the hypothalamus and is involved in the synthesis and storage of the hormone oxytocin a peptide essential for various physiological processes. During synthesis the protein undergoes cleavage to separate oxytocin and neurophysin 1 a carrier protein that aids in the transport and stabilization of oxytocin in neurosecretory granules.
Biological function summary

Oxytocin-neurophysin 1 plays an important role in the regulation of social behaviors reproductive functions and fluid homeostasis. This precursor is not part of a larger protein complex but neurophysin 1 serves as an essential carrier that binds and transports oxytocin to its target sites in the body. Oxytocin itself functions as a neuromodulator and hormone exerting effects on the uterine muscles and mammary glands promoting childbirth and lactation.

Pathways

The biosynthesis and release of oxytocin-neurophysin 1 are closely associated with the hypothalamic neurosecretory pathways. These pathways involve the neurohypophysis where oxytocin is released into the bloodstream. Additionally oxytocin interacts with the G-protein-coupled receptor OXTR to elicit its physiological effects. V1a and V2 receptors alongside oxytocin play roles in various signaling pathways that affect metabolic and cardiovascular functions.

Dysregulation of oxytocin-neurophysin 1 has been linked to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and autism spectrum disorders. In these conditions altered levels of oxytocin affect fluid balance and social behavior. Additionally changes in oxytocin levels often in tandem with altered vasopressin regulation associate with the development and exacerbation of these disorders.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Neurophysin 1 specifically binds oxytocin.. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed : 18174156).
See full target information OXT
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular metabolism 100:102220 PubMed40712884

2025

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica J Rea,Clarissa M Liu,Anna M R Hayes,Rita Ohan,Grace M Schwartz,Alexander G Bashaw,Molly E Klug,Lea Decarie-Spain,Yedam Park,Alicia E Kao,Valery Grinevich,Scott E Kanoski

Hippocampus 35:e70003 PubMed39949067

2025

Perinatal Protein Restriction Induces Anhedonic-Like Behavior: Disturbed Hippocampal Neurotrophic Signaling and Neuronal Structural Plasticity in Adult Offspring.

Applications

Unspecified application

Species

Unspecified reactive species

María C Gutiérrez,Ramiro G Comas Mutis,María C Perondi,Gastón D Calfa,Analía Valdomero
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com