Anti-p53 antibody
- Lab Essentials
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(12 제품이 사용된 논문 )
Rabbit Polyclonal P53 antibody. Suitable for IHC-P, IP, Flow Cyt, Flow Cyt (Intra), WB and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human TP53 aa 50-100.
대체 명칭 보기
P53, TP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p53 antibody (AB17990)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung cancer tissue labelling p53 with ab17990 at 1/5000 dilution. Detection : DAB.
- Flow Cyt (Intra)
Unknown
Flow Cytometry (Intracellular) - Anti-p53 antibody (AB17990)
ab17990 at 1.5ug/ml staining p53 in human Jurkat cell line by Flow Cytometery. Cells were fixed in 1.5% paraformaldehyde, and permeabilized in 90% methanol. A FITC-conjugated goat anti rabbit was used as secondary. The black line indicates control anti KLH IgG and the red line repersents ab17990 staining.
Reactivity 정보
특성 및 보관 정보
제형
Purification 테크닉
보관 버퍼
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
P53 functions to control cell division and apoptosis serving as a guardian of the genome by preventing mutation accumulation. It does not form part of a larger complex under normal conditions but interacts with various other molecules to execute its functions. p53 can activate or suppress the transcription of numerous genes involved in cell cycle arrest DNA repair and programmed cell death allowing it to halt the progression of damaged cells and trigger repair mechanisms or eliminate those that cannot be repaired.
Pathways
P53 acts within several key biological pathways such as the p53 signaling pathway and the intrinsic apoptotic pathway. Its activity involves interaction with proteins like MDM2 which regulates p53 through ubiquitin-mediated degradation and ATM kinase which phosphorylates p53 in response to DNA damage. These interactions ensure appropriate cellular responses during stress and are vital for maintaining homeostasis.
제품 프로토콜
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타겟 정보
제품이 사용된 논문 (12)
Recent publications for all applications. Explore the 전체 목록 and refine your search
International journal of molecular sciences 26: PubMed40141421
2025
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Unspecified application
Species
Unspecified reactive species
Journal of nanobiotechnology 21:117 PubMed37005668
2023
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Unspecified reactive species
EMBO molecular medicine 12:e11466 PubMed32150356
2020
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Unspecified reactive species
Investigational new drugs 38:634-649 PubMed31240514
2019
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Gene 712:143944 PubMed31233763
2019
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Unspecified reactive species
Gene 711:143939 PubMed31220581
2019
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Unspecified reactive species
Experimental and therapeutic medicine 16:4193-4200 PubMed30344694
2018
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Cell chemical biology 25:761-774.e5 PubMed29681526
2018
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Unspecified application
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Unspecified reactive species
Scientific reports 7:40960 PubMed28102346
2017
Applications
ChIP, IP
Species
Human, Human
BMC cancer 15:644 PubMed26400193
2015
Applications
IHC
Species
Unspecified reactive species
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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