AB50246

Anti-PADI3 / PAD3 antibody

Name: Anti-PADI3 / PAD3 antibody
Brand: Abcam Limited
SKU: AB50246
Rating: 4 (1 reviews)

(1 리뷰)

(21 제품이 사용된 논문 )

Rabbit Polyclonal PADI3 / PAD3 antibody. Suitable for IP, ELISA, WB and reacts with Human samples. Cited in 21 publications. Immunogen corresponding to Synthetic Peptide within Human PADI3.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ELISA, IP

applications

Immunogen

Synthetic Peptide within Human PADI3. The exact immunogen used to generate this antibody is proprietary information.

Q9ULW8

Specificity

This antibody reacts specifically with the 75kDa PADI3 / PAD3 protein. It shows no cross reactivity with the other isoforms.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PADI3 also known as PAD3 is an enzyme that belongs to the peptidylarginine deiminase family. It converts arginine residues into citrullines in the presence of calcium ions an activity known as citrullination or deimination. PADI3 has a molecular mass of approximately 74 kDa. Expression of this enzyme is found mainly in hair follicles skin and possibly other epithelial tissues where it modifies structural proteins important for tissue organization and function.

Biological function summary

PADI3 plays a role in the formation of the hair shaft by modifying trichohyalin a core structural protein and possibly other substrates within hair matrix keratinocytes. It contributes to the stabilization and structural integrity of hair and skin proteins. Although not massive in function alone PADI3 may work as part of a complex with other proteins to achieve these modifications effectively.

Pathways

PADI3 fits into the intricate web of keratinization and epidermal differentiation processes. It is part of pathways that involve protein deimination alongside proteins such as PAD2 and PAD1 which work together to modify and stabilize intermediate filaments and other structural protein components within the skin and hair.

PADI3 is linked most commonly to hair and skin-related conditions including some forms of alopecia and psoriasis. Studies suggest the enzyme might interact with keratin proteins influencing the abnormal keratinization observed in these disorders. Mutations in PADI3 as well as related proteins like keratin may disrupt normal protein modification and aggregation leading to these pathological conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Catalyzes the deimination of arginine residues of proteins.

See full target information PADI3

대체 명칭 보기

PAD3, PDI3, PADI3, Protein-arginine deiminase type-3, Peptidylarginine deiminase III, Protein-arginine deiminase type III

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제품이 사용된 논문 (21)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 25: PubMed39201398

2024

Targeting Peptidylarginine Deiminase 3 to Efficiently Suppress Herpes Simplex Virus Type 2 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Selina Pasquero,Francesca Gugliesi,Matteo Biolatti,Camilla Albano,Greta Bajetto,Linda Trifirò,Stefano Raviola,Valentina Dell'Oste,Marco De Andrea

PLoS pathogens 19:e1011849 PubMed38055760

2023

Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors.

Applications

Unspecified application

Species

Unspecified reactive species

Selina Pasquero,Francesca Gugliesi,Matteo Biolatti,Valentina Dell'Oste,Camilla Albano,Greta Bajetto,Gloria Griffante,Linda Trifirò,Bianca Brugo,Stefano Raviola,Davide Lacarbonara,Qiao Yang,Sen Sudeshna,Leonard Barasa,Hafeez Haniff,Paul R Thompson,Santo Landolfo,Marco De Andrea

International journal of molecular sciences 23: PubMed36361903

2022

Differential, Stage Dependent Detection of Peptidylarginine Deiminases and Protein Deimination in Lewy Body Diseases-Findings from a Pilot Study.

Applications

Unspecified application

Species

Unspecified reactive species

Audrey Mercer,Zane Jaunmuktane,Mariya Hristova,Sigrun Lange

ACS omega 7:28378-28387 PubMed35990454

2022

Autocitrullination and Changes in the Activity of Peptidylarginine Deiminase 3 Induced by High Ca Concentrations.

Applications

Unspecified application

Species

Unspecified reactive species

Mizuki Sawata,Hiroki Shima,Kazutaka Murayama,Toshitaka Matsui,Kazuhiko Igarashi,Kazumasa Funabashi,Kenji Ite,Kenji Kizawa,Hidenari Takahara,Masaki Unno

International journal of molecular sciences 23: PubMed35955829

2022

A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species.

Applications

Unspecified application

Species

Unspecified reactive species

Jameel M Inal,Mariya Hristova,Sigrun Lange

International journal of molecular sciences 23: PubMed35563075

2022

Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats ().

Applications

Unspecified application

Species

Unspecified reactive species

Stefania D'Alessio,Hang Cheng,Liam Eaton,Igor Kraev,Matthew E Pamenter,Sigrun Lange

Antiviral research 200:105278 PubMed35288208

2022

Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2.

Applications

Unspecified application

Species

Unspecified reactive species

Selina Pasquero,Francesca Gugliesi,Gloria Griffante,Valentina Dell'Oste,Matteo Biolatti,Camilla Albano,Greta Bajetto,Serena Delbue,Lucia Signorini,Maria Dolci,Santo Landolfo,Marco De Andrea

Biology 10: PubMed33805829

2021

Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer ().

Applications

Unspecified application

Species

Unspecified reactive species

Stefania D'Alessio,Stefanía Thorgeirsdóttir,Igor Kraev,Karl Skírnisson,Sigrun Lange

International journal of molecular sciences 22: PubMed33573274

2021

Peptidylarginine Deiminase Inhibitor Application, Using Cl-Amidine, PAD2, PAD3 and PAD4 Isozyme-Specific Inhibitors in Pancreatic Cancer Cells, Reveals Roles for PAD2 and PAD3 in Cancer Invasion and Modulation of Extracellular Vesicle Signatures.

Applications

Unspecified application

Species

Unspecified reactive species

Pinar Uysal-Onganer,Stefania D'Alessio,Maria Mortoglou,Igor Kraev,Sigrun Lange

Frontiers in immunology 11:651 PubMed32411128

2020

Deimination Protein Profiles in Reveal Plasma and Extracellular Vesicle-Specific Signatures Relating to Immunity, Metabolic Function, and Gene Regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Michael F Criscitiello,Igor Kraev,Lene H Petersen,Sigrun Lange

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PADI3 / PAD3 antibody

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (21)

Product promise