AB233741

Anti-PAR1/Thrombin Receptor antibody [5E2E6]

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(5 제품이 사용된 논문 )

Mouse Monoclonal PAR1/Thrombin Receptor antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human F2R aa 1-200.

대체 명칭 보기

CF2R, PAR1, TR, F2R, Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

Formalin-fixed, paraffin-embedded human rectum cancer tissue stained for PAR1/Thrombin Receptor using ab233741 at 1/200 dilution in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

All lanes:

Western blot - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (ab233741) at 1/500 dilution

All lanes:

Recombinant human PAR1/Thrombin Receptor protein

Predicted band size: 47 kDa

false

Supplier Data

Western blot - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

All lanes:

Western blot - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (ab233741) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) cell lysate

Lane 2:

PAR1/Thrombin Receptor-hIgGFc transfected HEK-293 cell lysate

Predicted band size: 47 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

5E2E6

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human F2R aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P25116

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/1000", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

보관 버퍼

Preservative: 0.05% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed : 1672265, PubMed : 8136362). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (By similarity). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (PubMed : 10079109). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (PubMed : 30568593, PubMed : 34831181).

See full target information F2R

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

CytoJournal 22:34 PubMed40260066

2025

A disintegrin-like and metalloproteinase 15 facilitates glioblastoma proliferation and metastasis through activation of the protease-activated receptor 1.

Applications

Unspecified application

Species

Unspecified reactive species

Rong Ren,Zuowei Li,Qiong Fang

Experimental & molecular medicine 56:2631-2641 PubMed39617789

2024

Distribution and impact of p16 senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Soon Sang Park,Young-Kyoung Lee,Young Hwa Kim,So Hyun Park,Hee Young Kang,Jin Cheol Kim,Dong Jun Kim,Su Bin Lim,Gyesoon Yoon,Jang-Hee Kim,Yong Won Choi,Tae Jun Park

Journal of experimental & clinical cancer research : CR 43:231 PubMed39155374

2024

SelK promotes glioblastoma cell proliferation by inhibiting β-TrCP1 mediated ubiquitin-dependent degradation of CDK4.

Applications

Unspecified application

Species

Unspecified reactive species

Jizhen Li,Lingling Zhao,Zerui Wu,Shirui Huang,Junyu Wang,Yuanyuan Chang,Li Liu,Honglei Jin,Jianglong Lu,Chuanshu Huang,Qipeng Xie,Haishan Huang,Zhipeng Su

Neural regeneration research 18:1339-1346 PubMed36453421

2022

Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Chen,Huiyuan Ji,Nan Jiang,Yingjie Wang,Yue Zhou,Zhenjie Zhu,Yuming Hu,Yongjun Wang,Aihong Li,Aisong Guo

Cardiovascular diabetology 20:77 PubMed33812377

2021

PAR-4/Ca-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Alessandra Giannella,Giulio Ceolotto,Claudia Maria Radu,Arianna Cattelan,Elisabetta Iori,Andrea Benetti,Fabrizio Fabris,Paolo Simioni,Angelo Avogaro,Saula Vigili de Kreutzenberg

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PAR1/Thrombin Receptor antibody [5E2E6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

Western blot - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

Western blot - Anti-PAR1/Thrombin Receptor antibody [5E2E6] (AB233741)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise