AB235947

Anti-PBLD antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal PBLD antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PBLD aa 1 to C-terminus.

대체 명칭 보기

MAWBP, PBLD, Phenazine biosynthesis-like domain-containing protein, MAWD-binding protein, Unknown protein 32 from 2D-page of liver tissue, MAWDBP

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBLD antibody (AB235947)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBLD antibody (AB235947)

Paraffin-embedded human kidney tissue stained for PBLD using ab235947 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PBLD aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P30039

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PBLD also known as Phenazine Biosynthesis-Like Protein Domain is a protein with an approximate mass of 40 kDa. It is expressed in various tissues including the liver and kidney. PBLD possesses structural domains that resemble those found in the phenazine biosynthesis family suggesting its involvement in redox processes. Researchers have yet to fully clarify its mechanical role but its conserved domains hint at significant enzymatic functions in cellular metabolism.

Biological function summary

The role of PBLD appears linked to modulation of oxidative stress responses and metabolic processes. PBLD is part of larger protein complexes that regulate intracellular metabolic pathways. Its involvement in these complexes enables it to impact cellular balance in response to environmental or cellular stresses. This function suggests a protective role in maintaining cellular homeostasis and potentially implicates PBLD in detoxification processes within the cell.

Pathways

PBLD participates in metabolic and oxidative stress response pathways specifically the glutathione metabolism and the pentose phosphate pathway. It interacts with other proteins involved in these processes such as NADPH-producing enzymes and components of the oxidative defense system. These interactions allow PBLD to contribute to cellular redox balance and metabolic flux connecting it to essential cellular functions.

PBLD has shown associations with liver disorders and certain metabolic syndromes. For example altered expression of PBLD may relate to hepatic steatosis in conjunction with proteins such as CYP450 enzymes affecting liver metabolism. It also exhibits potential connections to metabolic syndrome where it might influence pathways involving insulin resistance and lipid metabolism indicating its broader role in metabolic health conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response (PubMed : 39362857, PubMed : 39589880, PubMed : 39779683). PBLD enhances IFN-I signaling via multiple pathways (PubMed : 39362857, PubMed : 39589880, PubMed : 39779683). Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication (PubMed : 39362857). Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (PubMed : 39779683). Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection (PubMed : 39589880). Acts as a tumor suppressor, regulating development of various cancers (PubMed : 23687415, PubMed : 26594798).

See full target information PBLD

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 19:469 PubMed34798872

2021

Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3.

Applications

Unspecified application

Species

Unspecified reactive species

Qingsong Jin,Liangyan Lin,Tiantian Zhao,Xiaoyan Yao,Yaqin Teng,Dongdong Zhang,Yongjun Jin,Meizi Yang

Cell cycle (Georgetown, Tex.) 19:3277-3288 PubMed33121324

2020

Long noncoding RNA MEG3 suppresses cell proliferation, migration and invasion, induces apoptosis and paclitaxel-resistance via miR-4513/PBLD axis in breast cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mingzhi Zhu,Fang Wang,Hailong Mi,Lin Li,Jing Wang,Mingli Han,Yuanting Gu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PBLD antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PBLD antibody (AB235947)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise