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AB243024

Anti-PCOLCE antibody [CL6567]

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(1 출판물)

Mouse Monoclonal PCOLCE antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PCOLCE aa 250-400.

대체 명칭 보기

PCPE1, PCOLCE, Procollagen C-endopeptidase enhancer 1, Procollagen COOH-terminal proteinase enhancer 1, Type 1 procollagen C-proteinase enhancer protein, Type I procollagen COOH-terminal proteinase enhancer, PCPE-1, Procollagen C-proteinase enhancer 1

1 이미지
Western blot - Anti-PCOLCE antibody [CL6567] (AB243024)
  • WB

Supplier Data

Western blot - Anti-PCOLCE antibody [CL6567] (AB243024)

All lanes:

Western blot - Anti-PCOLCE antibody [CL6567] (ab243024) at 1 µg/mL

All lanes:

U-2197 cell lysate

Predicted band size: 48 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CL6567

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PCOLCE aa 250-400. The exact immunogen used to generate this antibody is proprietary information.

Q15113

Epitope

Binds to an epitope located within the peptide sequence PEKTEESPSAPDAPT as determined by overlapping synthetic peptides.

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대체품

Primary Antibodies

AB154261

Anti-PCOLCE antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCOLCE antibody (AB154261)

  • 0
  • 0
Primary Antibodies

AB220040

Anti-PCOLCE antibody

Immunocytochemistry/ Immunofluorescence - Anti-PCOLCE antibody (AB220040)

  • 0
  • 0

보완 제품

Assay Kits

AB313921

Human PCOLCE ELISA Kit

Sandwich ELISA - Human PCOLCE ELISA Kit (AB313921)

  • 0
  • 0
Primary Antibodies

AB7778

Anti-Collagen III antibody

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen III antibody (AB7778)

  • 4
  • 24
Primary Antibodies

AB138492

Anti-Collagen I antibody [EPR7785]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)

  • 4
  • 37
Primary Antibodies

AB7046

Anti-Collagen V antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen V antibody (AB7046)

  • 5
  • 11
Primary Antibodies

AB182744

Anti-Collagen VI antibody [EPR17072]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen VI antibody [EPR17072] (AB182744)

  • 4
  • 7
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
Purification 관련 사항
Purified from TCS.
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PCOLCE known as Procollagen C-endopeptidase enhancer is a glycoprotein with an approximate mass of 55 kDa. It resides mainly in the extracellular matrix playing a role in collagen processing. PCOLCE enhances the activity of the enzyme procollagen C-proteinase which is critical for converting procollagen to collagen by cleaving its C-terminal propeptide. PCOLCE expression occurs in tissues such as skin tendons and cartilage where collagen is abundant.
Biological function summary

PCOLCE serves as an enhancer of enzyme activity important for proper collagen maturation. This protein strongly associates with the biosynthesis of collagen fibrils being part of the larger complex responsible for proper collagen assembly. The effective regulation of collagen fibrils is essential for maintaining structural integrity and strength of various tissues such as the skin and bone matrix.

Pathways

PCOLCE plays an important role in the collagen biosynthesis and modifying pathways. It collaborates closely with other proteins like BMP1 (Bone Morphogenetic Protein 1) which also participates in the procollagen processing activity. Through its precise regulation PCOLCE affects tissue repair and development pathways ensuring efficient collagen synthesis and deposition critical for functional extracellular matrix formation.

Mutations or dysregulation in PCOLCE can potentially relate to connective tissue disorders such as Ehlers-Danlos syndrome. In these conditions improper collagen processing occurs affecting tissue elasticity and strength. Studies suggest that abnormal PCOLCE activity may also influence fibrosis where excessive collagen deposition leads to tissue and organ dysfunction. In these contexts PCOLCE interaction with proteins like BMP1 and other collagen-modifying enzymes is significant affecting the progression of such disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
See full target information PCOLCE
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine (Cambridge, Mass.) 30:277 PubMed39725889

2024

Investigating the inflammatory mechanism of notoginsenoside R1 in Diabetic nephropathy via ITGB8 based on network pharmacology and experimental validation.

Applications

Unspecified application

Species

Unspecified reactive species

ChangYan Li,Chen Geng,JiangMing Wang,Luyao Shi,JingYuan Ma,Zhang Liang,WenXing Fan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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