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AB243025

Anti-PCP4 antibody [CL5306]

5

(1 리뷰)

|

(1 출판물)

Mouse Monoclonal PCP4 antibody. Suitable for IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PCP4 aa 1 to C-terminus.

대체 명칭 보기

PEP19, PCP4, Calmodulin regulator protein PCP4, Brain-specific polypeptide PEP-19, Purkinje cell protein 4

6 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling PCP4 with ab243025 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)

Negative control - Formalin-fixed, paraffin-embedded human tonsil tissue stained for PCP4 with ab243025 at a 1 : 500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)

Formalin-fixed, paraffin-embedded human cerebellum tissue stained for PCP4 with ab243025 at a 1 : 500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue labelling PCP4 with ab243025 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)

Formalin-fixed, paraffin-embedded rat cerebellum tissue stained for PCP4 with ab243025 at a 1 : 500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCP4 antibody [CL5306] (AB243025)

Formalin-fixed, paraffin-embedded mouse cerebellum tissue stained for PCP4 with ab243025 at a 1 : 500 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CL5306

Isotype

IgG1

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PCP4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P48539

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대체품

Primary Antibodies

AB197377

Anti-PCP4 antibody

Western blot - Anti-PCP4 antibody (AB197377)

  • 0
  • 0

보완 제품

Primary Antibodies

AB16046

Anti-FOXP2 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody (AB16046)

  • 5
  • 20
Primary Antibodies

AB218011

Anti-Myelin Basic Protein antibody [EPR21188] - Oligodendrocyte Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody [EPR21188] - Oligodendrocyte Marker (AB218011)

  • 5
  • 5
Primary Antibodies

AB312324

Anti-BASP1 antibody [EPR28066-51]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-BASP1 antibody [EPR28066-51] (AB312324)

  • 0
  • 0
Primary Antibodies

AB281588

Anti-MAP2 antibody [RM1010] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-MAP2 antibody [RM1010] - Neuronal Marker (AB281588)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
Purification 관련 사항
Purified from TCS.
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PCP4 also known as Purkinje cell protein 4 functions as a calcium-binding protein predominantly involved in the regulation of calmodulin signaling. It weighs approximately 7 kDa and exhibits a high expression in the central nervous system especially in Purkinje cells of the cerebellum. PCP4 also shows expression in the hippocampus and other brain regions suggesting its role in neuronal activities and functions.
Biological function summary

PCP4 regulates calcium-dependent signaling pathways by interacting with calmodulin. It plays an important role in modulating neural signaling and plasticity impacting synaptic function and neuronal communication. PCP4 is not part of a large complex instead it works directly with calmodulin to influence calcium dynamics therefore affecting various neuronal processes.

Pathways

PCP4 participates actively in calcium-signaling pathways which impact neuronal excitability and synaptic transmission. It closely interacts through these pathways with calmodulin potentially affecting other downstream effectors like kinase enzymes. By modulating these pathways PCP4 influences neurotransmission and can alter neuronal circuit functions which is important for learning and memory processes.

PCP4 has a significant link with certain neurological conditions including schizophrenia and autism spectrum disorders. Changes in the expression or mutation of PCP4 impact neuronal signaling and excitability contributing to the pathology of these conditions. PCP4's interaction with calmodulin may also influence these diseases as altered calcium-signaling dynamics are often observed in these disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed : 19106096, PubMed : 23204517, PubMed : 27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed : 21491429).
See full target information PCP4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine (Cambridge, Mass.) 30:277 PubMed39725889

2024

Investigating the inflammatory mechanism of notoginsenoside R1 in Diabetic nephropathy via ITGB8 based on network pharmacology and experimental validation.

Applications

Unspecified application

Species

Unspecified reactive species

ChangYan Li,Chen Geng,JiangMing Wang,Luyao Shi,JingYuan Ma,Zhang Liang,WenXing Fan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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