AB126614

Anti-PDCD2 antibody [EPR7159]

RabMAb
Recombinant
각 태그의 뜻

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Rabbit Recombinant Monoclonal PDCD2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

RP8, ZMYND7, PDCD2, uS5 assembly chaperone PDCD2, Programmed cell death protein 2, Zinc finger MYND domain-containing protein 7, Zinc finger protein Rp-8

2 이미지

Lab

Western blot - Anti-PDCD2 antibody [EPR7159] (AB126614)

ab126614 shows low sensitivity; therefore, we recommend ab133324 as an alternative.

Blocking and diluting buffer and concentration : 5% NFDM/TBST.

Lanes 1 - 3:

Western blot - Anti-PDCD2 antibody [EPR7159] (ab126614) at 1/1000 dilution

Lanes 4 - 6:

Western blot - Anti-PDCD2 antibody [EPR7158] (<a href='/ko/products/primary-antibodies/pdcd2-antibody-epr7158-ab133324'>ab133324</a>) at 1/1000 dilution

Lanes 1 and 4:

293T (human embryonic kidney epithelial cell) whole cell lysate at 20 µg

Lanes 2 and 5:

HeLa (human cervix adenocarcinoma epithelial cell) whole cell lysate at 20 µg

Lanes 3 and 6:

Ramos (human Burkitt's lymphoma B lymphocyte) whole cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Observed band size: 39 kDa

false

Exposure time: 20s

Unknown

Western blot - Anti-PDCD2 antibody [EPR7159] (AB126614)

All lanes:

Western blot - Anti-PDCD2 antibody [EPR7159] (ab126614) at 1/1000 dilution

Lane 1:

293T cell lysate at 10 µg

Lane 2:

HeLa cell lysate at 10 µg

Secondary

All lanes:

Goat Anti-rabbit HRP at 1/2000 dilution

Predicted band size: 39 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR7159

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The programmed cell death protein 2 (PDCD2) plays a significant role in apoptosis also known as programmed cell death. It has alternate names such as RP8 and it is composed of approximately 38 kDa. PDCD2 expression occurs widely across various tissues which indicates a basic function in cellular processes. The protein is typically localized within the nucleus and holds a zinc finger motif that suggests its ability to interact with nucleic acids impacting gene transcription and apoptosis mechanisms.

Biological function summary

PDCD2 influences cell proliferation and apoptosis which makes it an important factor in maintaining cellular homeostasis. Researchers have identified PDCD2 as a part of the nucleosome assembly that contributes to chromatin organization. This assembly implicates PDCD2 in DNA replication and transcription regulation. By influencing these processes PDCD2 supports normal cell cycle progression affirming its importance in cellular growth and division.

Pathways

Programmed cell death and cell cycle pathways are among the significant processes involving PDCD2. It interacts with the p53 pathway an important regulator of the cell cycle and apoptosis. This interaction highlights the importance of PDCD2 in genomic stability and stress responses. PDCD2 also associates with BCL-2 family proteins which further integrates its function with apoptotic and survival pathways showcasing its role in controlling cell fate.

PDCD2 has a connection to cancer and autoimmune diseases. Its dysregulation can lead to uncontrolled cell growth frequently observed in malignancies such as leukemia. PDCD2 downregulation is associated with an increase in tumorigenic behaviors relating to its interaction with proteins like p53 that are often mutated or dysfunctional in cancers. In autoimmune disorders PDCD2 implications suggest its role in abnormal immune cell apoptosis leading to prolonged immune cell survival which contributes to pathological autoimmunity.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Chaperone for ribosomal protein uS5; cotranslationally associates with uS5 and accompanies the ribosomal protein to assembly sites in the nucleus; appears to function redundantly to PDCD2L.

See full target information PDCD2

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

JCI insight 10: PubMed41059573

2025

Unique epithelial proliferative transcriptomic signature in proton pump inhibitor-responsive pediatric eosinophilic esophagitis.

Applications

Unspecified application

Species

Unspecified reactive species

Somdutta Chakraborty,Ankit Sharma,Sahiti Marella,Christian F Rizza,Patrick A O'Brien,Varsha Ganesan,Gila Idelman,Susie Min,Mayee Chen,Talaya McCright-Gill,Nancy Gonzalez,Alexandros D Polydorides,Paul S Foster,Simon P Hogan,Mirna Chehade

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PDCD2 antibody [EPR7159]

Western blot - Anti-PDCD2 antibody [EPR7159] (AB126614)

Western blot - Anti-PDCD2 antibody [EPR7159] (AB126614)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise