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AB236957

Anti-PDE6C antibody

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Rabbit Polyclonal PDE6C antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PDE6C aa 250-500.

대체 명칭 보기

PDEA2, PDE6C, cGMP phosphodiesterase 6C

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-PDE6C antibody (AB236957)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PDE6C antibody (AB236957)

A549 (human lung carcinoma cell line) cells labeling PDE6C (green) using ab236957 at 1/66 dilution in ICC/IF, followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG (H+L). Counterstained with DAPI (blue).

The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. Cells were then incubated with primary antibody overnight at 4°C.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human PDE6C aa 250-500. The exact immunogen used to generate this antibody is proprietary information.

P51160

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보완 제품

Proteins & Peptides

AB271683

Recombinant mouse PDE6C protein (Active) (GST tag N-Terminus)

SDS-PAGE - Recombinant mouse PDE6C protein (Active) (GST tag N-Terminus) (AB271683)

  • 0
  • 0
Primary Antibodies

AB122280

Anti-ADAT2 antibody

Immunocytochemistry - Anti-ADAT2 antibody (AB122280)

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  • 2
Primary Antibodies

AB236874

Anti-Visfatin antibody [EPR21980]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Visfatin antibody [EPR21980] (AB236874)

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  • 0
Primary Antibodies

AB64803

Anti-TUSC5 antibody

Western blot - Anti-TUSC5 antibody (AB64803)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Chicken": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Phosphodiesterase 6C (PDE6C) also known as cone phosphodiesterase is an important enzyme in the phototransduction pathway. It functions mechanically by hydrolyzing cyclic GMP (cGMP) into GMP a critical step in the visual signal transduction process. The PDE6C protein has a molecular mass of approximately 99 kDa. It is chiefly expressed in cone photoreceptor cells of the retina playing a pivotal role in converting light into electrical signals essential for vision.
Biological function summary

PDE6C plays a significant part in the visual process by regulating levels of cGMP in cone cells. It forms a critical component of the phototransduction cascade where it associates with other subunits including alpha beta and gamma subunits to form a functional enzyme complex. This complex adjusts cGMP levels in response to light exposure contributing to the adaptation of photoreceptors to varying light conditions helping modulate visual acuity and color differentiation.

Pathways

PDE6C is deeply embedded in the phototransduction pathway an important cascade for light perception. The hydrolysis of cGMP by PDE6C interacts with the cyclic nucleotide-gated (CNG) ion channels regulating the flow of ions and influencing the membrane potential of cone cells. It shows a relationship with other phototransduction proteins such as guanylate cyclase complementing the regulation of cGMP within the visual signaling pathway.

PDE6C mutations or malfunctions can lead to cone dystrophies and achromatopsia both impacting vision. These conditions result from disrupted cGMP levels in cone cells impairing normal phototransduction. Dysfunctions in PDE6C have indirect associations with GNAT2 another protein critical to phototransduction; this linkage influences the same pathway leading to compromised visual signal processing and associated retinal diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.
See full target information PDE6C
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of clinical investigation 135: PubMed39817450

2025

Clonal analysis of SepSecS-specific B and T cells in autoimmune hepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Kramer,Federico Mele,Sandra Jovic,Blanca Maria Fernandez,David Jarrossay,Jun Siong Low,Christiane Sokollik,Magdalena Filipowicz Sinnreich,Sylvie Ferrari-Lacraz,Giorgina Mieli-Vergani,Diego Vergani,Antonio Lanzavecchia,Antonino Cassotta,Benedetta Terziroli Beretta-Piccoli,Federica Sallusto
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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