JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB138402

Anti-PDLIM5/ENH (phospho Y251) antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal PDLIM5/ENH phospho Y251 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

대체 명칭 보기

ENH, L9, PDLIM5, PDZ and LIM domain protein 5, Enigma homolog, Enigma-like PDZ and LIM domains protein

1 이미지
Western blot - Anti-PDLIM5/ENH (phospho Y251) antibody (AB138402)
  • WB

Unknown

Western blot - Anti-PDLIM5/ENH (phospho Y251) antibody (AB138402)

All lanes:

Western blot - Anti-PDLIM5/ENH (phospho Y251) antibody (ab138402) at 1/500 dilution

All lanes:

K562 cell extracts at 30 µg

Predicted band size: 64 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

대체품

Primary Antibodies

AB224385

Anti-PDLIM5/ENH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PDLIM5/ENH antibody (AB224385)

  • 0
  • 0
Primary Antibodies

AB85967

Anti-PDLIM5/ENH antibody

Immunoprecipitation - Anti-PDLIM5/ENH antibody (AB85967)

  • 0
  • 0
Primary Antibodies

AB196559

Anti-PDLIM5/ENH antibody

Immunocytochemistry/ Immunofluorescence - Anti-PDLIM5/ENH antibody (AB196559)

  • 0
  • 0

보완 제품

Primary Antibodies

AB196559

Anti-PDLIM5/ENH antibody

Immunocytochemistry/ Immunofluorescence - Anti-PDLIM5/ENH antibody (AB196559)

  • 0
  • 0
Primary Antibodies

AB238135

Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-PSD95 antibody [EPR23124-118] - Synaptic Marker (AB238135)

  • 5
  • 5
Primary Antibodies

AB254349

Anti-Synapsin I antibody [EPR23531-50] - Synaptic Marker

BOND RX™ Validated|Lab Essentials|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Synapsin I antibody [EPR23531-50] - Synaptic Marker (AB254349)

  • 4
  • 1
Primary Antibodies

AB32127

Anti-Synaptophysin antibody [YE269] - Synaptic Marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-Synaptophysin antibody [YE269] - Synaptic Marker (AB32127)

  • 5
  • 39
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab138402 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PDLIM5/ENH also known as Enhancer of Lim Domain Protein 5 is a cytoskeletal protein with a molecular mass of approximately 62 kDa. This protein is primarily expressed in heart and skeletal muscle tissues. PDLIM5/ENH binds to actin filaments and is involved in organizing the cytoskeleton. It acts as an adapter or scaffold protein linking other proteins to the cytoskeleton and helping in maintaining structural integrity and function in muscle cells.
Biological function summary

PDLIM5/ENH plays a significant role in cardiac muscle development and function. It is also a part of the protein complex that interacts with other cytoskeletal proteins to stabilize actin filament structures. This interaction is important for muscle contraction and cellular signaling. PDLIM5/ENH is also involved in transducing mechanical signals into biochemical signals which affect cell differentiation and growth.

Pathways

PDLIM5/ENH integrates into important signaling pathways like the MAPK and Wnt pathways. In the MAPK pathway PDLIM5/ENH interacts with proteins involving cell growth and differentiation such as ERK. Through the Wnt pathway it plays a role in tissue development and regeneration by working alongside proteins like beta-catenin. These pathways highlight its contribution to essential cellular processes that affect muscle and cardiac function.

PDLIM5/ENH is associated with cardiac hypertrophy and dilated cardiomyopathy. Alterations in its function can impact cardiac muscle structure leading to pathological changes. Additionally its interaction with proteins like desmin in muscle tissues links it to muscle disorder pathologies. Understanding PDLIM5/ENH's role in these diseases may provide insights into therapeutic targets for cardiac and muscle-related disorders.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation.
See full target information PDLIM5 pY251
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Toxicology and applied pharmacology 289:58-69 PubMed26348139

2015

A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown.

Applications

Unspecified application

Species

Unspecified reactive species

Jone A Stanley,Joe A Arosh,Robert C Burghardt,Sakhila K Banu
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com