AB25494

PE Anti-CD24 antibody [30-F1]

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(5 제품이 사용된 논문 )

Anti-CD24 antibody [30-F1] conjugated to PE - suitable for flow cytometry, and reacts with mouse samples. Clone [30-F1] is a rat monoclonal antibody cited in 32 publications.

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Flow Cytometry - PE Anti-CD24 antibody [30-F1] (AB25494)

Flow Cyt

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Flow Cytometry - PE Anti-CD24 antibody [30-F1] (AB25494)

Flow cytometry analysis staining CD24 in mouse splenocytes using ab25494 at a dilution of 0.1 μg/10⁶ cells.

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

30-F1

Isotype

IgG2c

Light chain 타입

kappa

Conjugation

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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제품 세부 정보

This antibody has been shown to be involved in the blockade of B cell lymphoblast aggregation. It has also been shown to be useful in studies of B cell ontology.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

보관 버퍼

pH: 7.3 Preservative: 0.09% Sodium azide Constituents: PBS, 16% Sucrose

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

+4°C

보관 정보

Store in the dark

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.

Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (By similarity). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed : 19264983). Plays a role in the control of autoimmunity (PubMed : 20200274).

See full target information Cd24

대체 명칭 보기

CD24, Cd24a, Ly-52, Cd24, Signal transducer CD24, Lymphocyte antigen 52, M1/69-J11D heat stable antigen, Nectadrin, R13-Ag, X62 heat stable antigen, HSA

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록and refine your search

Journal of orthopaedic surgery and research 20:198 PubMed40001262

2025

Mechanism of lncRNA ZFAS1 mediating nucleus pulposus cell pyroptosis in intervertebral disc degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yuchun Fu,Leilei Zhu,Bingxu Ma

Journal of Cancer 16:1618-1630 PubMed39991585

2025

Stigmasterol Attenuates Triple-negative Breast Cancer Stem Cell Properties by Inhibiting JAK3.

Applications

Unspecified application

Species

Unspecified reactive species

Ruijuan Zhou,Yuzhu Zhang,Leqin Xu,Yang Sun

Histology and histopathology 40:733-743 PubMed39380528

2024

Mechanism of KMT2D-mediated epigenetic modification in IL-1β-induced nucleus pulposus cell degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjiang Liu,Haiquan Liu,Zuyu Meng,Wensheng Zhang

American journal of translational research 13:10075-10093 PubMed34650682

2021

HNSC exosome-derived MIAT improves cognitive disorders in rats with vascular dementia the miR-34b-5p/CALB1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Qi,Xiaojun Hou,Chunfeng Jin,Xi Chen,Chengli Pan,Hongjuan Fu,Leifeng Song,Jujun Xue

Journal of immunology (Baltimore, Md. : 1950) 167:1141-4 PubMed11466327

2001

Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).

Applications

Unspecified application

Species

Unspecified reactive species

H Arase,T Saito,J H Phillips,L L Lanier

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD24 antibody [30-F1]

Flow Cytometry - PE Anti-CD24 antibody [30-F1] (AB25494)

주요 정보

Host species

Clonality

Clone number

Isotype

Light chain 타입

Conjugation

Excitation/Emission

Carrier free

Reacts with

Applications

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (5)

Product promise