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AB278765

PE Anti-STAT5 (phospho Y694) antibody [Stat5Y694-G11]

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Rabbit Recombinant Monoclonal STAT5a phospho Y694 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Immunogen corresponding to Synthetic Peptide within Human STAT5A pY694.

대체 명칭 보기

STAT5, STAT5A, Signal transducer and activator of transcription 5A

1 이미지
Flow Cytometry - PE Anti-STAT5 (phospho Y694) antibody [Stat5Y694-G11] (AB278765)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-STAT5 (phospho Y694) antibody [Stat5Y694-G11] (AB278765)

Flow cytometric analysis of NIH3T3 cells unstained and treated with imatinib as negative control (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using ab278765.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Unconjugated

    Anti-STAT5 (phospho Y694) antibody [Stat5Y694-G11]

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

Stat5Y694-G11

Isotype

IgG

Light chain 타입

kappa

Conjugation

PE

Excitation/Emission

Ex: 480;565nm, Em: 578nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

Synthetic Peptide within Human STAT5A pY694. The exact immunogen used to generate this antibody is proprietary information.

P42229

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보완 제품

Assay Kits

AB126429

Human STAT5 (Tyr694) In-Cell ELISA Kit

In-Cell ELISA - Human STAT5 (Tyr694) In-Cell ELISA Kit (AB126429)

  • 0
  • 0
Primary Antibodies

AB210232

PE/Cy7® Anti-FOXP3 antibody [3G3]

Flow Cytometry (Intracellular) - PE/Cy7® Anti-FOXP3 antibody [3G3] (AB210232)

  • 0
  • 0
Primary Antibodies

AB230670

Anti-STAT5 antibody [9F7]

Flow Cytometry (Intracellular) - Anti-STAT5 antibody [9F7] (AB230670)

  • 0
  • 0
Primary Antibodies

AB278618

FITC Anti-JNK1 (phospho T183 + Y185) antibody [SAPKT183Y185-A11]

Recombinant

Flow Cytometry - FITC Anti-JNK1 (phospho T183 + Y185) antibody [SAPKT183Y185-A11] (AB278618)

  • 0
  • 0
Primary Antibodies

AB319353

PE Anti-PFKM + PFKL antibody [EPR11904]

RabMAb|Recombinant

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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제품 세부 정보

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
보관 버퍼
Preservative: 0.09% Sodium azide Constituents: PBS, 0.2% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store in the dark
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Signal Transducer and Activator of Transcription 5 commonly known as STAT5 is a member of the STAT protein family. It weighs approximately 94 kDa. STAT5 usually exists in two closely related forms STAT5a and STAT5b with both playing similar roles but having slightly different activity. This protein is widely expressed found in cells like lymphocytes epithelial cells and endothelial cells indicating its importance in various tissues.
Biological function summary

STAT5 acts as a transcription factor that modulates gene expression by binding to specific DNA sequences. It often forms part of a larger complex when activated. This complex relocation to the nucleus triggers transcriptional activities essential for cell growth differentiation and survival. As it interacts with other proteins STAT5 plays an important role in cytokine signaling particularly in response to interleukins and growth hormones.

Pathways

STAT5 is important in the JAK-STAT signaling pathway. This pathway is activated by cytokines and growth factors leading to STAT5 phosphorylation and its subsequent translocation into the nucleus. The interaction with Janus kinases (JAKs) facilitates this process. STAT5 also plays a significant role in the MAPK pathway linking it to various cellular responses and functions.

STAT5 has a strong association with oncological conditions like leukemia and lymphomas. Aberrant activation or dysregulation of STAT5 can lead to uncontrolled cell proliferation and survival contributing to cancer. Furthermore STAT5 is linked with autoimmune diseases with its malfunction affecting immune response and leading to disorders. In these conditions proteins like BCL-XL often interact with STAT5 influencing cell survival pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Carries out a dual function : signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
See full target information STAT5A pY694
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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