JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB236503

Anti-Pea3 antibody [OTI5C11]

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Mouse Monoclonal Pea3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETV4 aa 1 to C-terminus.

대체 명칭 보기

E1AF, PEA3, ETV4, ETS translocation variant 4, Adenovirus E1A enhancer-binding protein, E1A-F, Polyomavirus enhancer activator 3 homolog, Protein PEA3

1 이미지
Western blot - Anti-Pea3 antibody [OTI5C11] (AB236503)
  • WB

Ap

Western blot - Anti-Pea3 antibody [OTI5C11] (AB236503)

All lanes:

Western blot - Anti-Pea3 antibody [OTI5C11] (ab236503) at 1/2000 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY control, cell lysate at 5 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) transfected with pCMV6-ENTRY Pea3, cell lysate at 5 µg

Predicted band size: 54 kDa,65 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI5C11

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human ETV4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P43268

style
left-column

대체품

Primary Antibodies

AB70425

Anti-Pea3 antibody [1A2G3]

Flow Cytometry - Anti-Pea3 antibody [1A2G3] (AB70425)

  • 3
  • 2
Primary Antibodies

AB189826

Anti-Pea3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Pea3 antibody (AB189826)

  • 4
  • 3

보완 제품

Primary Antibodies

AB182858

Anti-Bcl-2 antibody [EPR17509]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-2 antibody [EPR17509] (AB182858)

  • 5
  • 13
Primary Antibodies

AB51034

Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker (AB51034)

  • 5
  • 6
Primary Antibodies

AB6276

Anti-beta Actin antibody [AC-15] - Loading Control

KO Validated|Lab Essentials

Western blot - Anti-beta Actin antibody [AC-15] - Loading Control (AB6276)

  • 5
  • 94
Primary Antibodies

AB20346

Anti-Vimentin antibody [VI-10]

KO Validated|Lab Essentials

Western blot - Anti-Vimentin antibody [VI-10] (AB20346)

  • 5
  • 21
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Pea3 also called PEA3 or ETV4 functions as a transcription factor from the ETS family. It has a mass of approximately 55 kDa. This protein regulates gene expression by binding to specific DNA sequences. Pea3 is mainly expressed in the brain lung and liver tissues where it influences the transcription of a range of target genes. It plays an important role in mediating cellular responses to extracellular signals.
Biological function summary

Pea3 influences key processes like cell proliferation differentiation and migration. It often operates within larger protein complexes to execute these roles. Pea3 has been shown to regulate genes involved in development and oncogenic processes by interacting with co-factors in transcriptional complexes. By activating or repressing the transcription of specific genes Pea3 contributes to the dynamic regulation of cellular environments.

Pathways

Several intracellular signaling pathways involve Pea3 in integrating cellular responses to external stimuli. Notably Pea3 plays a role in the MAPK/ERK pathway where it works alongside proteins like ERK and other transcription factors to mediate cell growth and differentiation. Pea3 also participates in the PI3K/AKT pathway influencing cell survival and metabolism. In these pathways Pea3 acts as a bridge linking extracellular signals to transcriptional outputs.

Pea3 connects to cancer progression and metastasis. Overexpression of Pea3 is associated with various cancers including breast and lung cancer where it interacts with proteins like matrix metalloproteinases (MMPs) to promote metastasis. Pea3 also links to neurological disorders by influencing genes involved in brain development and function demonstrating its widespread significance in disease contexts.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Transcriptional activator (PubMed : 19307308, PubMed : 31552090). Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborization of specific motor neuron axons within their target muscles (By similarity). Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons (By similarity). May play a role in keratinocyte differentiation (PubMed : 31552090).. (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'.
See full target information ETV4
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Translational lung cancer research 13:3152-3174 PubMed39669999

2024

Construction and validation of a prognostic model based on oxidative stress-related genes in non-small cell lung cancer (NSCLC): predicting patient outcomes and therapy responses.

Applications

Unspecified application

Species

Unspecified reactive species

Dongfeng Sun,Jie Lu,Wenhua Zhao,Xiaozheng Chen,Changyan Xiao,Feng Hua,Per Hydbring,Esteban C Gabazza,Alfredo Tartarone,Xiaoming Zhao,Wenfeng Yang

Disease markers 2023:8143581 PubMed36815135

2023

Transcription Activation of Rab8A by PEA3 Augments Progression of Esophagus Cancer by Activating the Wnt/-Catenin Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shusheng Cai,Xiumei Liu,Weiran Gao,Lianhua Ye,Qiming Zhong,Xin Zhang
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com