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AB235322

Anti-PECI/ECI2 antibody

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Rabbit Polyclonal PECI/ECI2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ECI2 aa 100-250.

대체 명칭 보기

DRS1, HCA88, PECI, ECI2, Enoyl-CoA delta isomerase 2, DRS-1, Diazepam-binding inhibitor-related protein 1, Dodecenoyl-CoA isomerase, Hepatocellular carcinoma-associated antigen 88, Renal carcinoma antigen NY-REN-1, DBI-related protein 1, pECI

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PECI/ECI2 antibody (AB235322)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PECI/ECI2 antibody (AB235322)

Paraffin-embedded human liver tissue stained for PECI/ECI2 using ab235322 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ECI2 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

O75521

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보완 제품

Primary Antibodies

AB134953

Anti-Ubiquitin antibody [EPR8830]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Ubiquitin antibody [EPR8830] (AB134953)

  • 4
  • 3
Primary Antibodies

AB52866

Anti-alpha Tubulin antibody [EP1332Y] - Loading Control

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-alpha Tubulin antibody [EP1332Y] - Loading Control (AB52866)

  • 5
  • 31
Proteins & Peptides

AB99327

Recombinant Human PECI/ECI2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PECI/ECI2 protein (His tag N-Terminus) (AB99327)

  • 0
  • 0
Primary Antibodies

AB179434

Anti-Ubiquitin (linkage-specific K63) antibody [EPR8590-448]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ubiquitin (linkage-specific K63) antibody [EPR8590-448] (AB179434)

  • 5
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/4998", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PECI also known as ECI2 or peroxisomal delta(3)delta(2)-enoyl-CoA isomerase plays an important role in the beta-oxidation of unsaturated fatty acids. This enzyme with a molecular weight of approximately 33 kDa catalyzes the conversion of cis-double bonds in unsaturated fatty acyl-CoAs turning them into trans-double bonds which are useful for subsequent beta-oxidation. PECI primarily locates to the peroxisomes and is expressed in tissues with high metabolic rates like liver and heart.
Biological function summary

PECI contributes to the metabolism of fatty acids by ensuring effective breakdown of unsaturated fatty acids in peroxisomes. The enzyme participates as a solitary player and not part of a larger protein complex. By converting cis-double bonds to the trans configuration PECI aids in stabilizing the substrate for further catabolic processing. This facilitated breakdown is critical for energy production especially during fasting when fatty acids become a significant energy source.

Pathways

PECI's mechanical function integrates into the larger pathway of fatty acid metabolism especially the peroxisomal beta-oxidation pathway. This pathway teams with enzymes such as acyl-CoA oxidase and multifunctional enzyme protein to facilitate complete fatty acid degradation. PECI's transformation of unsaturated fatty acids ensures these substrates enter the pathway's main cycle aiding in continued lipid metabolism and maintaining cellular energy balance.

Disruptions in PECI function might lead to metabolic conditions like X-linked adrenoleukodystrophy or Refsum disease which both involve impaired fatty acid oxidation. The enzyme interacts with proteins like ABCD1 a transporter associated with peroxisomal biogenesis which holds significance in adrenoleukodystrophy. Proper function and regulation of PECI remain important for managing these disorders and ensuring uninterrupted fatty acid disassembly for cellular energy requirements.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.
See full target information ECI2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncology letters 21:185 PubMed33574924

2021

A comprehensive analysis of the expression, epigenetic and genetic changes of HNF1B and ECI2 in 122 cases of high-grade serous ovarian carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kristýna Němejcová,Michaela Bártů,Jan Hojný,Nikola Hájková,Romana Michálková,Eva Krkavcová,Ivana Stružinská,Hiep Quang Bui,Pavel Dundr,David Cibula,Kateřina Jirsová
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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