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AB242869

Anti-Pentraxin 3/PTX3 antibody [EPR18678-110] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal Pentraxin 3/PTX3 antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

대체 명칭 보기

TNFAIP5, TSG14, PTX3, Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TNF alpha-induced protein 5, TSG-14

1 이미지
Sandwich ELISA - Anti-Pentraxin 3/PTX3 antibody [EPR18678-110] - BSA and Azide free (Detector) (AB242869)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Pentraxin 3/PTX3 antibody [EPR18678-110] - BSA and Azide free (Detector) (AB242869)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab214570).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR18678-110

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB214570

Human Pentraxin 3 / PTX3 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Pentraxin 3 / PTX3 ELISA Kit (AB214570)

  • 5
  • 1
Primary Antibodies

AB281090

Anti-TWEAK antibody [EPR22899-249] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-TWEAK antibody [EPR22899-249] - BSA and Azide free (Detector) (AB281090)

  • 0
  • 0
Primary Antibodies

AB269404

Anti-MMP3 antibody [EPR22308-10] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-MMP3 antibody [EPR22308-10] - BSA and Azide free (Capture) (AB269404)

  • 0
  • 0
Primary Antibodies

AB275858

Anti-OX40L/TNFSF4 antibody [EPR23155-317] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-OX40L/TNFSF4 antibody [EPR23155-317] - BSA and Azide free (Capture) (AB275858)

  • 0
  • 0
Primary Antibodies

AB272766

Anti-SIRP alpha antibody [EPR22930-23] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-SIRP alpha antibody [EPR22930-23] - BSA and Azide free (Detector) (AB272766)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab242869 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Pentraxin3. The recommended pair for sandwich ELISA is:
Capture: ab242624, Human Pentraxin3 Capture Antibody (unconjugated)
Detector: ab242869, Human Pentraxin3 Detector Antibody (unconjugated)
The reference range value is 15.6 - 1000 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Pentraxin 3 (PTX3) also known as TSG-14 or TNF-Inducible Gene 14 Protein is an important component of the immune system. Mechanically PTX3 functions as part of the body's defense mechanism against pathogens and tissue damage. It has a molecular weight of approximately 42 kDa and is expressed in a range of tissues such as the immune cells endothelium and epithelial cells. Upon inflammatory signals these cells secrete PTX3 which quickly identifies microbial molecules and apoptotic cells.
Biological function summary

The role of PTX3 extends beyond simple pathogen recognition. It is involved in the regulation of inflammation and tissue homeostasis. As part of the pentraxin superfamily PTX3 plays a role in the formation of complexes with other molecules such as complement components. These interactions modulate the complement cascade an essential part of the innate immune response and influence the resolution of inflammation. PTX3 also interacts with extracellular matrix components stabilizing tissue structure during immune response.

Pathways

PTX3 integrates into vital immune signaling networks. It actively participates in the complement pathway where it regulates the activity of C1q and C3 key complement proteins. Additionally PTX3 connects with the Toll-like receptor (TLR) signaling pathway. This interaction helps modulate the body's response to microbial infections by influencing the activity of TLR4 among other related proteins which are fundamental in recognizing pathogen-associated molecular patterns.

PTX3 is linked to various inflammatory conditions. High levels of PTX3 often indicate a response to cardiovascular diseases such as atherosclerosis. In this context its interactions with C1q highlight its role in modulating disease progression. PTX3 also relates to autoimmune diseases like rheumatoid arthritis where its increased expression correlates with disease severity. In rheumatoid arthritis PTX3 can interact with pro-inflammatory cytokines like TNF-alpha exacerbating the inflammatory process.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
See full target information PTX3
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Product promise

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