AB52356

Anti-Perilipin 2 antibody

Name: Anti-Perilipin 2 항체 (ab52356) | Abcam
Brand: Abcam Limited
SKU: AB52356
Rating: 4 (3 reviews)

Anti-Perilipin 2 항체

(3 리뷰들)

(54 제품이 사용된 논문 )

Anti-Perilipin 2 antibody (ab52356) is a rabbit polyclonal antibody detecting Perilipin-2 in Western Blot, IHC-P. Suitable for Human, Mouse.

- Over 30 publications
- Trusted since 2007

대체 명칭 보기

ADFP, PLIN2, Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP

3 이미지

Unknown

Western blot - Anti-Perilipin 2 antibody (AB52356)

All lanes:

Western blot - Anti-Perilipin 2 antibody (ab52356) at 2 µg/mL

All lanes:

mouse liver lysate

Predicted band size: 48 kDa

Observed band size: 48 kDa

false

Supplier Data

Immunocytochemistry - Anti-Perilipin 2 antibody (AB52356)

ab52356 staining Perilipin-2 in HeLa cells at 1/50 dilution. Hoechst 33258 was used as a nuclear counterstain.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Perilipin 2 antibody (AB52356)

IHC-P

Lab

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Perilipin 2 antibody (AB52356)

Immunohistochemical analysis of mouse liver tissue staining Perilipin-2 using ab52356.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, ICC, WB

applications

Immunogen

Synthetic Peptide within Mouse Plin2. The exact immunogen used to generate this antibody is proprietary information.

P43883

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1/50 - 1/200", "ICC-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "" } } }

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제품 세부 정보

What is this antibody validated in?
Anti-Perilipin 2 antibody (ab52356) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse samples.

What is the molecular weight of Perilipin-2?
Anti-Perilipin 2 (ab52356) specifically detects a band for Perilipin-2 (UniProt: Q99541) at a molecular weight of 48kDa.

Trusted by the scientific community
Anti-Perilipin 2 (ab52356) was first used in a scientific publication in 2007 and has been cited over 30 times in peer-reviewed journals.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Constituents: PBS, 30% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein Perilipin-2 also known as PLIN2 ADFP or adipophilin has an approximate molecular weight of 48 kDa. It is primarily expressed in tissues involved in lipid metabolism like adipose tissue liver and muscle. The main role of Perilipin-2 is to coat lipid droplets in cells thereby regulating lipid storage and breakdown. This protein serves as a critical component of the lipid droplet surface providing structure and protecting the lipid core from excessive unregulated lipolysis.

Biological function summary

Perilipin-2 is a member of the PAT family proteins involved in lipid droplet formation and maintenance. It does not typically form part of larger complexes but it plays a significant role in cellular energy regulation by controlling lipid reserves. This regulation ensures an efficient balance between energy storage and mobilization. The presence and levels of Perilipin-2 can influence how cells respond to nutrients particularly during periods of energy surplus or fasting.

Pathways

Perilipin-2 is heavily involved in the regulation of lipid metabolic pathways and the storage-related signaling cascades. It interacts with key metabolic proteins including hormone-sensitive lipase (HSL) to modulate lipolysis. By doing so Perilipin-2 influences processes like fatty acid mobilization and glycerol release integrating perfectly into the cellular energy balance system. The protein is also related to perilipin another member of the lipid droplet-associated proteins emphasizing its participation in lipid metabolism.

Altered expression of Perilipin-2 can have implications in obesity and fatty liver disease. The protein is involved in the accumulation of lipid droplets which is a common feature in these conditions. Obesity and associated disorders often show elevated levels of Perilipin-2 which mirrors increased lipid storage capacity. The protein’s interplay with adipose tissue composition highlights its connection to obesity-related factors including other lipid droplet-associated proteins like adipose triglyceride lipase (ATGL) which influence the progression of metabolic diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.

See full target information PLIN2

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제품이 사용된 논문 (54)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:8077 PubMed40883260

2025

UBE3A promotes foam cell formation and counters remyelination by targeting ABCA1 for proteasomal degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Melanie Loix,Sam Vanherle,Laura Bolkaerts,Sanne G S Verberk,Mattijs Punt,Flore Wouters,Brecht Moonen,Rob Verhagen,Suzanne A E Van Wouw,Aldo Jongejan,Ben Distel,Ype Elgersma,Mansour Haidar,Noam Zelcer,Jerome J A Hendriks,Jeroen F J Bogie

Respiratory research 26:237 PubMed40618104

2025

A human PCLS model of lung injury and repair for discovery and pharmaceutical research.

Applications

Unspecified application

Species

Unspecified reactive species

Esther Bankole,Chun Wai Wong,Sally Kim,Matthew Hind,Charlotte H Dean

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e17332 PubMed40364726

2025

Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yueming Liu,Aidan E Gilchrist,Patrik K Johansson,Yuan Guan,Jaydon D Deras,Yu-Chung Liu,Sofia Ceva,Michelle S Huang,Renato S Navarro,Annika Enejder,Gary Peltz,Sarah C Heilshorn

Journal of neuroinflammation 22:117 PubMed40275347

2025

Astrocytic lipid droplets contain MHCII and may act as cogs in the antigen presentation machinery.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara Beretta,Abdulkhalek Dakhel,Khalid Eltom,Fredrik Rosqvist,Simon Uzoni,Tobias Mothes,John S Fletcher,Ulf Risérus,Dag Sehlin,Jinar Rostami,Wojciech Piotr Michno,Anna Erlandsson

iMeta 4:e272 PubMed40027481

2025

Cross-tissue multi-omics analyses reveal the gut microbiota's absence impacts organ morphology, immune homeostasis, bile acid and lipid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Shen,Weiming Liang,Ruizhen Zhao,Yang Chen,Yanmin Liu,Wei Cheng,Tailiang Chai,Yin Zhang,Silian Chen,Jiazhe Liu,Xueting Chen,Yusheng Deng,Zhao Zhang,Yufen Huang,Huanjie Yang,Li Pang,Qinwei Qiu,Haohao Deng,Shanshan Pan,Linying Wang,Jingjing Ye,Wen Luo,Xuanting Jiang,Xiao Huang,Wanshun Li,Elaine Lai-Han Leung,Lu Zhang,Li Huang,Zhimin Yang,Rouxi Chen,Junpu Mei,Zhen Yue,Hong Wei,Kristiansen Karsten,Lijuan Han,Xiaodong Fang

Cell death & disease 15:769 PubMed39438470

2024

β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Shuangqin Chen,Jiemei Li,Ye Liang,Meijia Zhang,Ziqi Qiu,Sirui Liu,HaoRan Wang,Ye Zhu,Shicong Song,Xiaotao Hou,Canzhen Liu,Qinyu Wu,Mingsheng Zhu,Weiwei Shen,Jinhua Miao,Fan Fan Hou,Youhua Liu,Cheng Wang,Lili Zhou

Journal of lipid research 65:100635 PubMed39187042

2024

Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Wang,Jiaxin Zhou,Qi Yang,Xinmeng Li,Yifu Qiu,Yansong Zhang,Min Liu,Alan Jian Zhu

Nature communications 15:5489 PubMed38942786

2024

A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain.

Applications

Unspecified application

Species

Unspecified reactive species

Sofia Madsen,Ana C Delgado,Christelle Cadilhac,Vanille Maillard,Fabrice Battiston,Carla Marie Igelbüscher,Simon De Neck,Elia Magrinelli,Denis Jabaudon,Ludovic Telley,Fiona Doetsch,Marlen Knobloch

British journal of pharmacology 181:3610-3626 PubMed38812293

2024

Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver.

Applications

Unspecified application

Species

Unspecified reactive species

Marine Andres,Nathalie Hennuyer,Khamis Zibar,Marie Bicharel-Leconte,Isabelle Duplan,Emmanuelle Enée,Emmanuelle Vallez,Adrien Herledan,Anne Loyens,Bart Staels,Benoit Deprez,Peter van Endert,Rebecca Deprez-Poulain,Steve Lancel

Nature metabolism 6:1253-1267 PubMed38789798

2024

Weak neuronal glycolysis sustains cognition and organismal fitness.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Jimenez-Blasco,Jesús Agulla,Rebeca Lapresa,Marina Garcia-Macia,Veronica Bobo-Jimenez,Dario Garcia-Rodriguez,Israel Manjarres-Raza,Emilio Fernandez,Yannick Jeanson,Spiro Khoury,Jean-Charles Portais,Daniel Padro,Pedro Ramos-Cabrer,Peter Carmeliet,Angeles Almeida,Juan P Bolaños

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Perilipin 2 antibody

Anti-Perilipin 2 항체

Western blot - Anti-Perilipin 2 antibody (AB52356)

Immunocytochemistry - Anti-Perilipin 2 antibody (AB52356)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Perilipin 2 antibody (AB52356)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Reagents, Controls & Accessories

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (54)

Product promise