AB238598

Anti-PEX1 antibody

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Rabbit Polyclonal PEX1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PEX1 aa 900 to C-terminus.

대체 명칭 보기

Peroxisomal ATPase PEX1, Peroxin-1, Peroxisome biogenesis disorder protein 1, Peroxisome biogenesis factor 1, PEX1

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-PEX1 antibody (AB238598)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PEX1 antibody (AB238598)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for PEX1 using ab238598 at a dilution of 1/100 in ICC/IF. Secondary used is an Alexa-Fluor^®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX1 antibody (AB238598)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX1 antibody (AB238598)

Paraffin-embedded human placenta tissue stained for PEX1 with ab238598 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PEX1 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43933

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein PEX1 also known as Peroxisomal Biogenesis Factor 1 plays an important role in peroxisomal function. PEX1 has a molecular mass of around 145 kDa and is widely expressed in human tissues. It belongs to the family of ATPases associated with various cellular activities (AAAs) which are essential molecular machines involved in diverse biological processes. PEX1 localizes mainly to the peroxisomes which means it takes part in the mechanics of peroxisome assembly and function.

Biological function summary

PEX1 interacts in collaboration with other peroxisomal proteins to facilitate the import of matrix proteins into the peroxisome. It exists as part of a hetero-oligomeric complex with PEX6 another AAA protein which forms an important part of the peroxisome biogenesis mechanism. PEX1's function in this complex contributes to the assembly maintenance and selective import operations within the peroxisome which are critical for cellular homeostasis and lipid metabolism.

Pathways

PEX1 contributes significantly within the peroxisomal biogenesis pathway where it works alongside proteins like PEX2 and PEX6 to maintain the functionality of the peroxisomes. This pathway is pivotal in multiple biological functions including plasmalogen synthesis and the breakdown of very-long-chain fatty acids. These processes tie closely with broader cellular metabolic pathways impacting both energy regulation and lipid processing.

Defects in PEX1 are linked to peroxisome biogenesis disorders such as Zellweger syndrome spectrum. These disorders result from compromised peroxisomal function leading to severe clinical symptoms and often fatal outcomes. PEX1 mutations disrupt its interaction with PEX6 impairing peroxisome function. This highlights its important role in peroxisome-related diseases and provides potential targets for future therapeutic strategies to treat these metabolic conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed : 11439091, PubMed : 16314507, PubMed : 16854980, PubMed : 21362118, PubMed : 29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed : 29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed : 29884772).

See full target information PEX1

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Science advances 7:eabf6063 PubMed34705506

2021

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Molly M Wilson,Céline Callens,Matthieu Le Gallo,Svetlana Mironov,Qiong Ding,Amandine Salamagnon,Tony E Chavarria,Roselyne Viel,Abena D Peasah,Arjun Bhutkar,Sophie Martin,Florence Godey,Patrick Tas,Hong Soon Kang,Philippe P Juin,Anton M Jetten,Jane E Visvader,Robert A Weinberg,Massimo Attanasio,Claude Prigent,Jacqueline A Lees,Vincent J Guen

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PEX1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PEX1 antibody (AB238598)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX1 antibody (AB238598)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise