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AB237534

Anti-PFDN2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal PFDN2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PFDN2.

대체 명칭 보기

PFD2, HSPC231, PFDN2, Prefoldin subunit 2

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-PFDN2 antibody (AB237534)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-PFDN2 antibody (AB237534)

PC-3 (human prostate adenocarcinoma cell line) cells stained for PFDN2 (green) using ab237534 at a 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PFDN2 antibody (AB237534)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PFDN2 antibody (AB237534)

Paraffin-embedded human pancreas tissue stained for PFDN2 with ab237534 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PFDN2.

Q9UHV9

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보완 제품

Primary Antibodies

AB190232

Anti-MRPL13 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL13 antibody (AB190232)

  • 0
  • 0
Primary Antibodies

AB157130

Anti-RPL12 antibody

Western blot - Anti-RPL12 antibody (AB157130)

  • 0
  • 0
Primary Antibodies

AB12323

Anti-JAB1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JAB1 antibody (AB12323)

  • 5
  • 2
Primary Antibodies

AB182568

Anti-C15orf24 antibody [EPR14097]

RabMAb|Recombinant

Western blot - Anti-C15orf24 antibody [EPR14097] (AB182568)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/20 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The prefoldin subunit 2 protein also known as PFDN2 plays an important role in chaperone-mediated protein folding. The protein has an approximate mass of 16 kDa. Scientists have observed its expression in many tissues including the brain liver and muscle. PFDN2 forms part of the prefoldin complex which participates in assisting nascent protein chains to fold correctly.
Biological function summary

PFDN2 functions to stabilize unfolding proteins by housing them in its prefoldin complex until they achieve proper conformation. This complex interacts directly with the cytoskeleton to maintain cellular architecture. The prefoldin complex consists of six subunits including PFDN2 that work together to perform this chaperone role effectively.

Pathways

PFDN2 contributes significantly to both the tubulin and actin folding pathways. This involves its interaction with chaperonins including CCT (chaperonin-containing TCP-1) important for the assembly of the cytoskeleton. It's vital in managing protein dynamics thereby influencing cellular activities like motility and division through its collaborative action with these pathways.

PFDN2 has associations with neurodegenerative conditions such as spinal muscular atrophy and amyotrophic lateral sclerosis. Researchers often study its interactions with other proteins such as SMN1 and SOD1 involved in these diseases. Dysregulation or mutations within PFDN2-related pathways could contribute to the progression of these disorders making it an area of active investigation for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
See full target information PFDN2
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in cell and developmental biology 9:801687 PubMed35096829

2022

Identification and Validation of Key Genes of Differential Correlations in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tingna Chen,Qiuming He,Zhenxian Xiang,Rongzhang Dou,Bin Xiong

OncoTargets and therapy 14:1007-1020 PubMed33603407

2021

Tandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Qiang Li,Ge Huang,Bing-Yao Lin,Dongzi Lin,Yan Ma,Zhao Zhang,Tao Chen,Jie Zhou
제품이 사용된 논문 모두 보기
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Product promise

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