JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB239479

Anti-PGA5 antibody [C4]

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Mouse Monoclonal PEPA5 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PGA5 aa 50-300.

대체 명칭 보기

Pepsin A-5, Pepsinogen-5, PGA5

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGA5 antibody [C4] (AB239479)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGA5 antibody [C4] (AB239479)

Paraffin-embedded human stomach tissue stained for PGA5 using ab239479 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-PGA5 antibody [C4] (AB239479)
  • WB

Supplier Data

Western blot - Anti-PGA5 antibody [C4] (AB239479)

All lanes:

Western blot - Anti-PGA5 antibody [C4] (ab239479) at 5 µg/mL

All lanes:

Recombinant human PGA5 protein

Predicted band size: 42 kDa

false

Western blot - Anti-PGA5 antibody [C4] (AB239479)
  • WB

Supplier Data

Western blot - Anti-PGA5 antibody [C4] (AB239479)

All lanes:

Western blot - Anti-PGA5 antibody [C4] (ab239479) at 5 µg/mL

All lanes:

Pig stomach lysate

Predicted band size: 42 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

C4

Isotype

IgG2b

Light chain 타입

kappa

Carrier free

No

Reacts with

Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PGA5 aa 50-300. The exact immunogen used to generate this antibody is proprietary information.

P0DJD9

style
left-column

보완 제품

Primary Antibodies

AB32572

Anti-beta Catenin antibody [E247] - ChIP Grade

BOND RX™ Validated|Advanced Validation|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Catenin antibody [E247] - ChIP Grade (AB32572)

  • 5
  • 75
Primary Antibodies

AB181876

Anti-Pepsin antibody

Western blot - Anti-Pepsin antibody (AB181876)

  • 0
  • 0
Reagents, Controls & Accessories

AB64201

Pepsin Solution (Antigen Retrieval)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Pepsin Solution (Antigen Retrieval) (AB64201)

  • 0
  • 0
Primary Antibodies

AB219412

Anti-Wnt3a antibody [EPR21889]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt3a antibody [EPR21889] (AB219412)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A/G
Purification 관련 사항
Purified from TCS.
보관 버퍼
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

{PGA5} also known as pepsinogen 5 or progastricsin serves as an inactive precursor that gets converted into the active enzyme pepsin A. It possesses a molecular mass of approximately 42 kDa. PGA5 is primarily expressed in the gastric mucosa particularly in the chief cells of the stomach. The enzyme exhibits an acidic pH optimum and plays a role in the initial digestion of proteins in the stomach through its proteolytic activity.
Biological function summary

The role of PGA5 centers around protein digestion within the stomach. It is part of a larger protein complex interacting with other pepsinogens and hydrolyzing proteins into peptides. This function is integral in breaking down food proteins into absorbable units assisting in nutrient uptake and the general digestive process. Its activity depends upon the acidic environment present in the stomach where it becomes activated to exert its enzymatic function.

Pathways

PGA5 holds significance in the gastric digestion pathway. It interacts with related proteins such as other pepsinogens and chymosin forming an ensemble vital for protein digestion. PGA5 also crosses paths with the aspartic protease pathway which includes related proteins like pepsin C and cathepsin E. These pathways ensure the coordinated breakdown and processing of dietary proteins reflecting PGA5's contributions to gastrointestinal physiology.

PGA5 links to gastric ulcer and peptic ulcer disorders. Changes in PGA5 expression and activity can influence the protective mucus layer contributing to ulcer development. Additionally alterations in its levels are associated with gastric carcinoma where it may influence tumor behavior. Within these contexts PGA5 interacts with proteins such as H/K-ATPase in ulcer-related pathways and matrix metalloproteinases in cancer progression highlighting its importance in both digestive and pathological states.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
See full target information PGA5
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Respiratory research 24:83 PubMed36927357

2023

Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.

Applications

Unspecified application

Species

Unspecified reactive species

Ana M Rodriguez-Piñeiro,Florian Jaudas,Nikolai Klymiuk,Andrea Bähr,Gunnar C Hansson,Anna Ermund
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com