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AB66968

Anti-PHF17 antibody

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Mouse Polyclonal PHF17 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human JADE1.
1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-PHF17 antibody (AB66968)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PHF17 antibody (AB66968)

Immunofluorescence of ab66968 on HeLa cells. (purified antibody concentration of 10ug/ml)

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human JADE1.

Q6IE81

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보완 제품

Primary Antibodies

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Primary Antibodies

AB109028

Anti-HP1 alpha antibody [EPR5777] - Heterochromatin marker

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Primary Antibodies

AB315887

Anti-Puromycin antibody [EPR27218-173]

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Immunocytochemistry/ Immunofluorescence - Anti-Puromycin antibody [EPR27218-173] (AB315887)

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Primary Antibodies

AB230823

Anti-non-muscle Myosin IIB/MYH10 antibody [EPR22564-23]

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Immunocytochemistry/ Immunofluorescence - Anti-non-muscle Myosin IIB/MYH10 antibody [EPR22564-23] (AB230823)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p>Requires purification with Protein A prior to ICC/IF.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PHF17 also known as Jade-1 is a protein that plays a significant role in chromatin remodeling and gene transcription. It weighs around 93 kDa and is expressed predominantly in the kidney although it shows presence in other tissues as well. PHF17 functions by recognizing specific histone modifications through its plant homeodomain (PHD) finger domains which enable it to bind to chromatin and influence gene expression.
Biological function summary

This protein is involved in essential cellular processes such as DNA damage response and apoptosis. PHF17 acts as part of larger complexes including its interaction with histone acetyltransferase HBO1 which facilitates the acetylation of histones and impacts chromatin structure. These interactions enable PHF17 to help regulate cell cycle progression contributing to the fine control of cellular proliferation and differentiation.

Pathways

PHF17 holds importance in the DNA damage response pathway and apoptotic pathways. In the DNA damage response it cooperates with proteins like ING4 and ING5 aligning with their roles in chromatin modulation and repair processes. Additionally PHF17's involvement in the apoptotic pathway connects it with p53 a well-known tumor suppressor protein helping mediate cell death under stress conditions or when DNA damage is excessive.

PHF17 has a connection to renal cell carcinoma reflecting its high expression in the kidney and its role in apoptosis. It interacts with proteins such as β-catenin suggesting a potential involvement in the Wnt signaling pathway which is often dysregulated in cancers. Furthermore PHF17's participation in DNA repair processes implicates its role in general cancer susceptibility highlighting its importance as a potential therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed : 16387653, PubMed : 19187766, PubMed : 20129055, PubMed : 24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed : 20129055, PubMed : 24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed : 15502158). Promotes apoptosis (PubMed : 16046545). May act as a renal tumor suppressor (PubMed : 16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed : 22654112).
See full target information JADE1

대체 명칭 보기

KIAA1807, PHF17, JADE1, Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oxidative medicine and cellular longevity 2017:9169146 PubMed29430286

2018

Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia El-Merhie,Eveline Baumgart-Vogt,Adrian Pilatz,Susanne Pfreimer,Bianca Pfeiffer,Oleg Pak,Djuro Kosanovic,Michael Seimetz,Ralph Theo Schermuly,Norbert Weissmann,Srikanth Karnati
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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