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AB235338

Anti-PIGX antibody

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Rabbit Polyclonal PIGX antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PIGX aa 1-250.

대체 명칭 보기

Phosphatidylinositol-glycan biosynthesis class X protein, PIG-X, PIGX

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIGX antibody (AB235338)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIGX antibody (AB235338)

Paraffin-embedded human rectum tissue stained for PIGX with ab235338 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIGX antibody (AB235338)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PIGX antibody (AB235338)

Paraffin-embedded human placenta tissue stained for PIGX with ab235338 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PIGX aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q8TBF5

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보완 제품

Primary Antibodies

AB235832

Anti-DDHD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDHD2 antibody (AB235832)

  • 0
  • 0
Primary Antibodies

AB118835

Anti-Corneodesmosin/S protein antibody

  • 0
  • 0
Primary Antibodies

AB136176

Anti-C Reactive Protein antibody [C2]

  • 5
  • 1
Assay Kits

AB108791

Mouse Albumin ELISA Kit

Competitive ELISA - Mouse Albumin ELISA Kit (AB108791)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PIGX also known as phosphatidylinositol glycan anchor biosynthesis class X functions as a subunit in the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway. PIGX has a mass of approximately 25 kDa and shows expression in various tissues including the liver and kidney. This protein participates in the early step of GPI anchor formation specifically involved in anchoring proteins to membranes.
Biological function summary

This target is essential in the complex that initiates GPI anchor biosynthesis. PIGX partners with PIG-A PIG-C and other components to catalyze the transfer of N-acetylglucosamine to phosphatidylinositol a critical step in the production of GPI anchors. These anchors tether proteins to the cell surface impacting processes such as signal transduction cell adhesion and protein sorting.

Pathways

PIGX plays a significant role in the GPI-anchor biosynthesis pathway and glycosylation. Within these pathways PIGX closely interacts with other GPI biosynthesis proteins such as PIG-M and PIG-L coordinating the sequential steps necessary for anchor formation. This pathway ensures that proteins anchor properly to cell membranes influencing cellular communication and immune responses.

Defects in PIGX can lead to conditions like paroxysmal nocturnal hemoglobinuria (PNH) and inherited GPI deficiency (IGD). PNH manifests due to mutations affecting GPI anchor synthesis which also involves the PIG-A protein. Additionally issues in the GPI biosynthesis pathway where PIGX is integral can result in neurologic disorders and developmental delays linked to IGD. Understanding PIGX's role aids in diagnosing and developing therapies for these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM.
See full target information PIGX
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular medicine 43:1747-1757 PubMed30720051

2019

Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zheng,Su Min,Bin Hu,Qin Liu,Yunqiang Wan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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