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AB224323

Anti-Pinkbar antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal Pinkbar antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BAIAP2L2 aa 350 to C-terminus.

대체 명칭 보기

UNQ9336/PRO34007, BAIAP2L2, BAR/IMD domain-containing adapter protein 2-like 2, Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, Planar intestinal- and kidney-specific BAR domain protein, BAI1-associated protein 2-like protein 2, Pinkbar

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pinkbar antibody (AB224323)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pinkbar antibody (AB224323)

Paraffin-embedded human small intestine tissue stained for Pinkbar using ab224323 at 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human BAIAP2L2 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6UXY1

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대체품

Primary Antibodies

AB135897

Anti-Pinkbar antibody

  • 2
  • 2

보완 제품

Primary Antibodies

AB243230

Anti-BST2/Tetherin antibody [EPR20202-150]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-BST2/Tetherin antibody [EPR20202-150] (AB243230)

  • 0
  • 0
Primary Antibodies

AB51067

Anti-Met (c-Met) antibody [EP1454Y] - N-terminal

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-Met (c-Met) antibody [EP1454Y] - N-terminal (AB51067)

  • 5
  • 13
Primary Antibodies

AB255607

Anti-ErbB3 / HER3 antibody [EPR22669-25]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB3 / HER3 antibody [EPR22669-25] (AB255607)

  • 0
  • 0
Primary Antibodies

AB289968

Anti-FGFR2 antibody [EPR24075-418]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGFR2 antibody [EPR24075-418] (AB289968)

  • 3
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as Pinkbar alternatively termed F-BAR domain containing 1 (F-BAR1) plays a mechanical role in membrane curvature modulation. Pinkbar is distinguished by its unique ability to form flat membrane protrusions unlike its BAR domain-containing relatives that create tubular structures. The protein has an approximate mass of 35 kDa and expresses widely with significant levels in intestinal epithelial cells. Its interaction with the actin cytoskeleton suggests a role in structural cell processes.
Biological function summary

Pinkbar influences the organization of the cell membrane and cytoskeletal dynamics. It integrates into membrane remodeling activities facilitating alterations in cell shape and motility. Pinkbar also participates as part of a larger protein complex that coordinates actin filament assembly. By binding to phospholipids and interacting with other cytoskeletal proteins Pinkbar conducts changes essential for cellular mechanical stability and communication.

Pathways

Pinkbar merges into cellular processes involving the actin cytoskeleton and the endocytosis pathway. The protein's performance in these pathways ensures efficient membrane-trafficking events and cell motility regulation. Pinkbar collaborates with proteins like actin and cortactin reinforcing the structural framework necessary for the upkeep of cellular architecture and endocytic functionality.

Pinkbar connects to conditions like intestinal inflammation and colorectal cancer. Its function in maintaining epithelial cell integrity underpins its role in disease; irregular activity can result in tissue damage or cancer progression. In intestinal inflammation Pinkbar interacts with proteins such as E-cadherin where disruptions in these interactions lead to compromised cell adhesion and increased disease susceptibility.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).
See full target information BAIAP2L2
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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of neuroinflammation 20:177 PubMed37507761

2023

Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Tahir Ali,Antonia N Klein,Keegan McDonald,Lovisa Johansson,Priyanka Ganguli Mukherjee,Martin Hallbeck,Katsumi Doh-Ura,Hermann M Schatzl,Sabine Gilch

Molecular biology of the cell 33:br6 PubMed35044843

2022

Ca entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Halford,Michael Bateschell,Peter G Barr-Gillespie

Journal of bone oncology 31:100393 PubMed34786330

2021

BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hongting Guo,Jing Peng,Juan Hu,Shichuan Chang,Huawen Liu,Hao Luo,Xiaohua Chen,Haiping Tang,Youhao Chen

The Journal of physiology 599:1173-1198 PubMed33151556

2020

Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.

Applications

Unspecified application

Species

Unspecified reactive species

Adam J Carlton,Julia Halford,Anna Underhill,Jing-Yi Jeng,Matthew R Avenarius,Merle L Gilbert,Federico Ceriani,Kimimuepigha Ebisine,Steve D M Brown,Michael R Bowl,Peter G Barr-Gillespie,Walter Marcotti
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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