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AB238643

Anti-PITPNC1 antibody

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Rabbit Polyclonal PITPNC1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PITPNC1.

대체 명칭 보기

Cytoplasmic phosphatidylinositol transfer protein 1, Mammalian rdgB homolog beta, Retinal degeneration B homolog beta, M-rdgB beta, MrdgBbeta, RdgBbeta, PITPNC1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNC1 antibody (AB238643)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNC1 antibody (AB238643)

Paraffin-embedded human thyroid tissue stained for PITPNC using ab238643 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNC1 antibody (AB238643)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNC1 antibody (AB238643)

Paraffin-embedded human adrenal gland tissue stained for PITPNC using ab238643 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PITPNC1.

Q9UKF7

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대체품

Primary Antibodies

AB68013

Anti-PITPNC1 antibody

Western blot - Anti-PITPNC1 antibody (AB68013)

  • 0
  • 0
Primary Antibodies

AB222078

Anti-PITPNC1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PITPNC1 antibody (AB222078)

  • 0
  • 0

보완 제품

Primary Antibodies

AB309489

Anti-ILF1 antibody [EPR27321-60]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ILF1 antibody [EPR27321-60] (AB309489)

  • 0
  • 0
Primary Antibodies

AB67886

Anti-ZNF331 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZNF331 antibody (AB67886)

  • 0
  • 0
Primary Antibodies

AB69036

Anti-TINAGL1 antibody

Western blot - Anti-TINAGL1 antibody (AB69036)

  • 4
  • 2
Primary Antibodies

AB85175

Anti-ATRAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATRAP antibody (AB85175)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PITPNC1 also known as Phosphatidylinositol Transfer Protein Cytoplasmic 1 is an important lipid transfer protein that binds to phosphatidylinositol and phosphatidylcholine. It plays a vital role in lipid signaling and membrane dynamics transporting phospholipids between cellular membranes. With a mass of approximately 36 kDa PITPNC1 is expressed in several tissues including the brain liver and lungs and highly in various cancerous tissues.
Biological function summary

PITPNC1 influences cellular growth movement and behavior. It is involved in the regulation of Golgi function and vesicular trafficking. PITPNC1 acts independently but can associate with other proteins influencing their functions. Studies suggest that PITPNC1 coordinates with vesicular transport complexes modifying intracellular signaling pathways.

Pathways

PITPNC1 integrates into key signaling cascades such as the phosphatidylinositol signaling pathway and the PI3K/AKT pathway. Its activity impacts PI3K signaling influencing cell proliferation and survival. PITPNC1 interacts with proteins like PIP2 and PIP3 which are important members of these pathways. Its role in these pathways offers insights into its broad functional impact in cells.

PITPNC1 has links to certain cancers and metabolic disorders. Its overexpression correlates with aggressive forms of cancer such as breast and colorectal cancer indicating its potential as a biomarker. In cancer PITPNC1 may facilitate metastasis by interacting with proteins like MMP9 (Matrix Metallopeptidase 9) and VEGFA (Vascular Endothelial Growth Factor A) influencing tumor progression and angiogenesis. Understanding PITPNC1's role offers opportunities for therapeutic targeting in these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Isoform 1. Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed : 10531358, PubMed : 22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, preferably binds to the C16 : 0/16 : 1 and C16 : 1/18 : 1 PA species (PubMed : 22822086).. Isoform 2. Catalyzes the transfer of phosphatidylinositol between membranes.
See full target information PITPNC1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Experimental and therapeutic medicine 21:549 PubMed33850521

2021

MicroRNA-363-3p inhibits tumor cell proliferation and invasion in oral squamous cell carcinoma cell lines by targeting SSFA2.

Applications

Unspecified application

Species

Unspecified reactive species

Liangming Zhu,Lei Zhang,Ying Tang,Fang Zhang,Chao Wan,Liang Xu,Ping Guo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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