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AB204800

Anti-PN-I antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal PN-I antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NT5C3A aa 150-350.

대체 명칭 보기

NT5C3, P5N1, UMPH1, HSPC233, NT5C3A, Cytosolic 5'-nucleotidase 3A, 7-methylguanosine phosphate-specific 5'-nucleotidase, Cytosolic 5'-nucleotidase 3, Cytosolic 5'-nucleotidase III, Pyrimidine 5'-nucleotidase 1, Uridine 5'-monophosphate hydrolase 1, p36, 7-methylguanosine nucleotidase, cN-III, P5'N-1, P5N-1, PN-I

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PN-I antibody (AB204800)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PN-I antibody (AB204800)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human stomach tissue labeling PN-I with ab204800 at 1/50.

Western blot - Anti-PN-I antibody (AB204800)
  • WB

Supplier Data

Western blot - Anti-PN-I antibody (AB204800)

All lanes:

Western blot - Anti-PN-I antibody (ab204800) at 1/100 dilution

Lane 1:

Negative Control

Lane 2:

HEK lysate

Secondary

All lanes:

HRP-conjugated Swine Anti-Rabbit antibody at 1/3000 dilution

Predicted band size: 38 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human NT5C3A aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q9H0P0

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보완 제품

Primary Antibodies

AB192036

Anti-Pin1 antibody [EPR18546-317]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Pin1 antibody [EPR18546-317] (AB192036)

  • 5
  • 4
Primary Antibodies

AB96084

Anti-NT5C2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NT5C2 antibody (AB96084)

  • 0
  • 0
Primary Antibodies

AB8105

Anti-p53R2 antibody

Western blot - Anti-p53R2 antibody (AB8105)

  • 5
  • 2
Primary Antibodies

AB155999

Anti-SDHC antibody [EPR11035(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDHC antibody [EPR11035(B)] (AB155999)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PN-I commonly known as Protease Nexin I serves as a serine protease inhibitor. It has a molecular mass of approximately 43 kDa. PN-I expression occurs predominantly in the nervous system and various cell types such as fibroblasts and endothelial cells. It regulates the activity of multiple proteases like thrombin urokinase and plasminogen activator. This regulation helps to ensure a balance in protease activity.
Biological function summary

PN-I plays a significant role in maintaining extracellular matrix homeostasis and modulating cellular processes like migration and proliferation. It is part of a complex with proteases that it inhibits forming stable complexes to neutralize their activity. Through its actions PN-I influences cell signaling and tissue remodeling having effects that are essential for physiological processes.

Pathways

PN-I interacts with the fibrinolytic and coagulation pathways. It modulates these pathways by inhibiting enzymes such as thrombin and urokinase impacting processes like blood clot formation and degradation. In the coagulation cascade PN-I effects relate closely to proteins like thrombin affecting blood homeostasis and ensuring a proper response to vascular injury.

PN-I has links to conditions such as thrombosis and tissue fibrosis. Alterations in PN-I expression or function can contribute to pathological states by disrupting protease regulation leading to excessive clot formation or tissue scarring. PN-I interacts with proteins involved in these diseases such as plasminogen activators highlighting its importance in maintaining proteolytic balance in tissues.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP) (PubMed : 24603684). CMP seems to be the preferred substrate (PubMed : 15968458).
See full target information NT5C3A
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer immunology research 9:665-681 PubMed33839687

2021

Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Owen Heath,Chiara Berlato,Eleni Maniati,Anissa Lakhani,Colin Pegrum,Panoraia Kotantaki,Samar Elorbany,Steffen Böhm,Simon T Barry,Alessandro Annibaldi,Desmond P Barton,Frances R Balkwill

Function (Oxford, England) 1:zqaa018 PubMed33074265

2020

Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel Lopez,Bahador Marzban,Xin Gao,Ellen Lauinger,Françoise Van den Bergh,Steven E Whitesall,Kimber Converso-Baran,Charles F Burant,Daniel E Michele,Daniel A Beard
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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