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AB151151

Anti-PNLDC1 antibody

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Rabbit Polyclonal PNLDC1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PNLDC1 aa 250-350.

대체 명칭 보기

Poly(A)-specific ribonuclease PNLDC1, PARN-like domain-containing protein 1, Poly(A)-specific ribonuclease domain-containing protein 1, HsPNLDC1, PNLDC1

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling PNLDC1 with ab151151 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling PNLDC1 with ab151151 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach tissue labelling PNLDC1 with ab151151 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNLDC1 antibody (AB151151)

Immunohistochemical analysis of paraffin-embedded Human pancreas tissue labeling PNLDC1 with ab151151 at 1/200.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PNLDC1 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

Q8NA58

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보완 제품

Primary Antibodies

AB177184

Anti-Histone H3 (di methyl K79) antibody [EPR17467] - ChIP Grade

RabMAb|Advanced Validation|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Histone H3 (di methyl K79) antibody [EPR17467] - ChIP Grade (AB177184)

  • 4
  • 3
Primary Antibodies

AB81289

Anti-CD34 antibody [EP373Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD34 antibody [EP373Y] (AB81289)

  • 4
  • 56
Primary Antibodies

AB176842

Anti-Histone H3 antibody [EPR16987] - Nuclear Marker and ChIP Grade

20ul selling size|RabMAb|Recombinant|Lab Essentials|Advanced Validation

Immunocytochemistry/ Immunofluorescence - Anti-Histone H3 antibody [EPR16987] - Nuclear Marker and ChIP Grade (AB176842)

  • 5
  • 15
Primary Antibodies

AB8580

Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade

BOND RX™ Validated

ChIP - Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (AB8580)

  • 5
  • 90
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PNLDC1 also referred to as PARN-like domain-containing 1 is a protein known for its role as a poly(A)-specific ribonuclease. It functions by trimming the poly(A) tails at the 3' end of RNA molecules which affects RNA stability and translation. PNLDC1 has an approximate mass of 61 kDa. Researchers have detected its expression predominantly in the testes indicating a role in germ cell development. This localization suggests PNLDC1's specific involvement in reproductive biology which marks its distinct function from its homologs.
Biological function summary

The activity of maintaining RNA stability places PNLDC1 as part of an exosome complex similar to the one where its related protein PARN functions. PNLDC1 likely contributes to spermatogenesis through its action in RNA processing. By trimming RNA tails it influences the maturation and maintenance of sperm cells highlighting its significance in reproduction. The protein's activity in RNA metabolism emphasizes its regulatory function in controlling gene expression at the RNA level.

Pathways

The significance of PNLDC1 in regulating RNA stability integrates it into essential biological processes such as the RNA decay pathway. The protein works alongside enzymes like Dicer which handle post-transcriptional control of RNA molecules synergizing to maintain RNA integrity. Within the RNA stability pathway its function intersects with RNA interference pathways sharing roles in ensuring correct RNA turnover and function within cells.

Researchers have associated PNLDC1 with certain reproductive impairments particularly spermatogenic failure. This failure links to suboptimal RNA processing where PNLDC1 function is important. Decreased activity of PNLDC1 can impact proteins like DAZL which play roles in germ cell development. Additionally disturbances in PNLDC1 function can contribute to testicular dysgenesis pointing to its potential as a marker for reproductive diseases and emphasizing its importance in diagnosing fertility issues.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed : 27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed : 27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed : 34347949).
See full target information PNLDC1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in oncology 11:681366 PubMed34136404

2021

N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis Differentially Regulating Ubiquitination of Targets.

Applications

Unspecified application

Species

Unspecified reactive species

Guoqing Zhu,Feng Wang,Haojie Li,Xiao Zhang,Qi Wu,Ya Liu,Mingping Qian,Susu Guo,Yueyue Yang,Xiangfei Xue,Fenyong Sun,Yongxia Qiao,Qiuhui Pan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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