AB171934

Anti-POGZ antibody

Name: Anti-POGZ antibody
Brand: Abcam Limited
SKU: AB171934
Rating: 3 (1 reviews)

(1 리뷰)

(5 제품이 사용된 논문 )

Rabbit Polyclonal POGZ antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human POGZ aa 1 to C-terminus.

대체 명칭 보기

KIAA0461, SUHW5, ZNF280E, ZNF635, Nbla00003, POGZ, Pogo transposable element with ZNF domain, Suppressor of hairy wing homolog 5, Zinc finger protein 280E, Zinc finger protein 635

3 이미지

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

Immunofluorescenct analysis of HeLa cells (chromosome spread preparations) labeling POGZ with ab171934 at 1/500 dilution and stained with Hoechst 33342.

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

Immunofluorescent analysis of Paraformaldehyde-fixed HeLa cells labeling POGZ with ab171934 at 1/500 dilution and stained with Hoechst 33342.

Supplier Data

Western blot - Anti-POGZ antibody (AB171934)

All lanes:

Western blot - Anti-POGZ antibody (ab171934) at 1/1000 dilution

Lane 1:

Crude extract of HeLa cells transfected with control siRNA

Lane 2:

Crude extract of HeLa cells transfected with POGZ siRNA

Predicted band size: 155 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human POGZ aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q7Z3K3

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purity

Whole antiserum

Purification 관련 사항

Sterilized by filtration through 0.22 µm membrane.

보관 버퍼

pH: 6.5 - 8.5

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

POGZ also known as Pogo Transposable Element with ZNF Domain is a zinc finger protein with a molecular weight of approximately 155 kDa. Scientists have studied POGZ for its role in transcription regulation. This protein localizes primarily in the nucleus and is expressed in various human tissues with higher expression levels observed in the brain. POGZ interacts with chromatin and may play a role in the regulation of gene expression through chromatin remodeling.

Biological function summary

POGZ influences genetic expression by participating in the chromatin modification process. It acts as a member of the protein complex that includes histone modifiers modifying the chromatin landscape to allow or restrict access for transcription machinery. The protein impacts neuronal differentiation and brain development among other processes therefore bearing significance in neurodevelopmental biology. It partners with several key proteins to achieve its biological functions contributing to the regulation of genes required for proper cellular function.

Pathways

More than one biological pathway has involved POGZ. Notably it participates in the chromatin remodeling pathway important for modulating chromatin structure and gene accessibility. POGZ interacts with proteins such as CHD4 part of the NuRD complex within these pathways. These interactions facilitate access to DNA regulating the transcription of genes tied to cellular differentiation and proliferation.

Genetics has linked POGZ to neurodevelopmental disorders such as intellectual disability and autism spectrum disorder (ASD). Mutations in the POGZ gene disrupt normal function contributing to these conditions. POGZ has connections with ATRX another protein associated with intellectual disabilities. Research continues to explore how these interactions contribute to the pathogenesis of neurodevelopmental disorders offering potential therapeutic targets in these conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed : 20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed : 26721387).

See full target information POGZ

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell reports 42:112867 PubMed37494184

2023

POGZ suppresses 2C transcriptional program and retrotransposable elements.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyun Sun,Tianzhe Zhang,Bei Tong,Linxi Cheng,Wei Jiang,Yuhua Sun

Molecular autism 13:24 PubMed35650610

2022

Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyun Sun,Linxi Cheng,Yuhua Sun

Cell reports 37:110089 PubMed34879283

2021

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.

Applications

Unspecified application

Species

Unspecified reactive species

Eirene Markenscoff-Papadimitriou,Fadya Binyameen,Sean Whalen,James Price,Kenneth Lim,Athena R Ypsilanti,Rinaldo Catta-Preta,Emily Ling-Lin Pai,Xin Mu,Duan Xu,Katherine S Pollard,Alex S Nord,Matthew W State,John L Rubenstein

EMBO reports 23:e51041 PubMed34758190

2021

POGZ promotes homology-directed DNA repair in an HP1-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

John Heath,Estelle Simo Cheyou,Steven Findlay,Vincent M Luo,Edgar Pinedo Carpio,Jeesan Lee,Billel Djerir,Xiaoru Chen,Théo Morin,Benjamin Lebeau,Martin Karam,Halil Bagci,Damien Grapton,Josie Ursini-Siegel,Jean-Francois Côté,Michael Witcher,Stéphane Richard,Alexandre Maréchal,Alexandre Orthwein

Nature communications 9:3848 PubMed30242288

2018

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.

Applications

Unspecified application

Species

Unspecified reactive species

Ho-Soo Lee,Zhonghui Lin,Sunyoung Chae,Young-Suk Yoo,Byung-Gyu Kim,Youngsoo Lee,Jared L Johnson,You-Sun Kim,Lewis C Cantley,Chang-Woo Lee,Hongtao Yu,Hyeseong Cho

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-POGZ antibody

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

Western blot - Anti-POGZ antibody (AB171934)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purity

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise