Anti-Polycystin 2 antibody

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Forms a nonselective cation channel (PubMed : 11854751, PubMed : 11991947, PubMed : 15692563, PubMed : 26269590, PubMed : 27071085, PubMed : 31441214, PubMed : 39009345). Can function as a homotetrameric ion channel or can form heteromer with PKD1 (PubMed : 31441214, PubMed : 33164752). Displays distinct function depending on its subcellular localization and regulation by its binding partners (PubMed : 11854751, PubMed : 11991947, PubMed : 27214281, PubMed : 29899465). In primary cilium functions as a cation channel, with a preference for monovalent cations over divalent cations that allows K(+), Na(+) and Ca(2+) influx, with low selectivity for Ca(2+) (PubMed : 27071085). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). In the endoplasmic reticulum, likely functions as a K(+) channel to facilitate Ca(2+) release (By similarity). The heterotetrameric PKD1/PKD2 channel has higher Ca(2+) permeability than homomeric PKD2 channel and acts as a primarily Ca(2+)-permeable channel (PubMed : 31441214). Interacts with and acts as a regulator of a number of other channels, such as TRPV4, TRPC1, IP3R, RYR2, ultimately further affecting intracellular signaling, to modulate intracellular Ca(2+) signaling (PubMed : 11854751, PubMed : 11991947, PubMed : 27214281, PubMed : 29899465). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed : 18695040). In cardiomyocytes, PKD2 modulates Ca(2+) release from stimulated RYR2 receptors through direct association (By similarity). Also involved in left-right axis specification via its role in sensing nodal flow; forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning (By similarity). Acts as a regulator of cilium length together with PKD1 (By similarity). Mediates systemic blood pressure and contributes to the myogenic response in cerebral arteries though vasoconstriction (By similarity).