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AB34020

Anti-Porcine SWC8 antibody [MIL3]

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Mouse Monoclonal Porcine SWC8 antibody. Suitable for Flow Cyt, IHC-Fr and reacts with Pig samples. Cited in 1 publication.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

MIL3

Isotype

IgM

Carrier free

No

Reacts with

Pig

Applications

IHC-Fr, Flow Cyt

applications

Specificity

This antibody recognises the porcine SWC8 cell surface antigen.

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Pig": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Use 50ul of the suggested working dilution to label 10^6 cells in 100ul. ab34020 has been used in two colour flow cytometry with MIL2 to distinguish between monocytes and granulocytes. <a href='/ko/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }

특성 및 보관 정보

제형
Liquid
Purity
Tissue culture supernatant
보관 버퍼
pH: 7.4 Preservative: 0.09% Sodium azide
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Porcine SWC8 also known as Porcine CD172a is a surface antigen with a mass of approximately 100 kDa. This glycoprotein is expressed on a wide range of cells including monocytes granulocytes macrophages and subsets of dendritic cells in pigs. Its expression on these immune cells indicates its important role in the cellular immune response where it participates in various processes by serving as a receptor and adhesion molecule.
Biological function summary

This protein is involved in the regulation of immune responses acting as an inhibitory receptor that impacts the signaling associated with phagocytic activity. It forms part of the cell signaling complex with SHP-1 and SHP-2 two phosphatases that modulate immune cell activation through dephosphorylation of specific sites. SWC8's function in signaling ensures proper modulation of immune responses balancing activation and inhibition to prevent excessive inflammation.

Pathways

Porcine SWC8 participates in immune response and signal transduction pathways. It is closely related to proteins involved in the SIRP (Signal Regulatory Protein) family pathway. This pathway includes interactions with other SIRP family proteins such as SIRPβ and CD47 which are critical for cell-cell communication and immune regulation. These interactions influence cell survival proliferation and migration playing an important role in maintaining immune homeostasis.

Porcine SWC8 relates to conditions affecting the immune system such as immunodeficiency and inflammation in pigs. The protein's association with regulatory pathways implies a functional connection to disorders where immune regulation is disrupted. Changes in SWC8 expression or function may relate to autoimmune diseases reflecting its importance in maintaining immune control. Through its role in signaling cascades disturbances in its activity could influence proteins like CD47 affecting how the immune system responds to internal and external threats.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of leukocyte biology 77:923-33 PubMed15767291

2005

Fibrocytes are potent stimulators of anti-virus cytotoxic T cells.

Applications

Unspecified application

Species

Unspecified reactive species

Carole Balmelli,Nicolas Ruggli,Kenneth McCullough,Artur Summerfield
제품이 사용된 논문 모두 보기

Product promise

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