AB251771

Anti-PPP1R3C antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal PPP1R3C antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PPP1R3C aa 1-150.

대체 명칭 보기

PPP1R5, PPP1R3C, Protein phosphatase 1 regulatory subunit 3C, Protein phosphatase 1 regulatory subunit 5, Protein targeting to glycogen, PP1 subunit R5, PTG

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Formalin-fixed, paraffin-embedded human heart tissue stained for PP1R3C with ab251771 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Formalin-fixed, paraffin-embedded human lung tissue stained for PP1R3C with ab251771 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for PP1R3C with ab251771 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Formalin-fixed, paraffin-embedded human liver tissue stained for PP1R3C with ab251771 at a 1/50 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-PPP1R3C antibody (AB251771)

Western blot analysis of RT-4 cell lysate labeling PPP1R3C with ab251771.

All lanes:

Western blot - Anti-PPP1R3C antibody (ab251771) at 0.04 µg/mL

All lanes:

RT-4 cell lysate

Predicted band size: 36 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PPP1R3C aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q9UQK1

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PPP1R3C also known as protein phosphatase 1 regulatory subunit 3C is a regulatory subunit of protein phosphatase 1 (PP1). This protein has a mass of approximately 34 kDa. PPP1R3C is mainly expressed in skeletal muscle and liver tissues. It acts by modulating glycogen metabolism where it impacts glycogen synthesis and breakdown. This regulation is achieved through altering the activity of PP1 which dephosphorylates diverse biological substrates to control various cellular functions.

Biological function summary

The PPP1R3C protein binds to glycogen and PP1 forming a complex with these substrates. This interaction plays a role in the regulation of glucose homeostasis by controlling glycogen synthesis and breakdown. Such processes are important for energy storage and release in muscle and liver tissues. By integrating within this complex PPP1R3C influences the activity and localization of PP1 facilitating efficient glycogen regulation.

Pathways

PPP1R3C participates in critical pathways like glycogen metabolism and insulin signaling. The protein is closely associated with key metabolic proteins such as glycogen synthase. Within these pathways PPP1R3C modifies the enzymatic activity of its pathway partners to balance glucose levels in response to insulin. This involvement supports metabolic flexibility and energy management in response to dietary changes.

PPP1R3C connects to insulin resistance and type 2 diabetes where its altered function may disrupt normal glycogen metabolism. The protein's dysfunction impacts glucose homeostasis and insulin signaling pathway contributing to the pathophysiology of these metabolic diseases. Additionally PPP1R3C interacts with proteins like glycogen synthase which play significant roles in the metabolic disturbances seen in such disorders. Understanding these interactions helps in devising strategies for targeted therapeutic interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.

See full target information PPP1R3C

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell death discovery 11:192 PubMed40263288

2025

QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yulai Zhou,Yan Gao,Yinghui Peng,Changjing Cai,Ying Han,Yihong Chen,Gongping Deng,Yanhong Ouyang,Hong Shen,Shan Zeng,Yangfeng Du,Zemin Xiao

The Journal of international medical research 52:3000605241282384 PubMed39628429

2024

RAB32 promotes glioma cell progression by activating the JAK/STAT3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sinan Zhang,Xudong Jiang,Qing Wei,Liji Huang,Zhuoyan Huang,Lina Zhang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PPP1R3C antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R3C antibody (AB251771)

Western blot - Anti-PPP1R3C antibody (AB251771)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Assay Kits

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise