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AB240507

Anti-PR3 antibody [PR3G-2]

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Mouse Monoclonal PR3 antibody. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing PRTN3 protein.

대체 명칭 보기

MBN, PRTN3, Myeloblastin, AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen, PR-3, PR3, NP-4

1 이미지
Flow Cytometry (Intracellular) - Anti-PR3 antibody [PR3G-2] (AB240507)
  • Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-PR3 antibody [PR3G-2] (AB240507)

Flow cytometric analysis of HL-60 (human promyelocytic leukemia cell line) cells labeling PR3 with ab240507 at a concentration of 2 μg/250000 cells (blue). Black line represents cells only, red line the isotype control.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • 519 FITC

    FITC Anti-PR3 antibody [PR3G-2]

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

PR3G-2

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

Flow Cyt (Intra)

applications

Immunogen

Cell preparation containing PRTN3 protein. The exact immunogen used to generate this antibody is proprietary information.

P24158

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대체품

Primary Antibodies

AB91182

FITC Anti-PR3 antibody [WGM2]

Flow Cytometry (Intracellular) - FITC Anti-PR3 antibody [WGM2] (AB91182)

  • 0
  • 0
Primary Antibodies

AB103632

Anti-PR3 antibody

Western blot - Anti-PR3 antibody (AB103632)

  • 0
  • 0
Primary Antibodies

AB202968

Anti-PR3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PR3 antibody (AB202968)

  • 0
  • 0
Primary Antibodies

AB133613

Anti-PR3 antibody [EPR6277]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PR3 antibody [EPR6277] (AB133613)

  • 0
  • 0
Primary Antibodies

AB191282

Anti-PR3 antibody

Western blot - Anti-PR3 antibody (AB191282)

  • 0
  • 0
Primary Antibodies

AB91181

Anti-PR3 antibody [WGM2]

  • 0
  • 0

보완 제품

Assay Kits

AB226902

Human PR3 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human PR3 ELISA Kit (AB226902)

  • 0
  • 0
Proteins & Peptides

AB316642

Recombinant Mouse PR3 Protein Standard (His tag)

Sandwich ELISA - Recombinant Mouse PR3 Protein Standard (His tag) (AB316642)

  • 0
  • 0
Sample Prep & Detection Kits

AB236553

Alexa Fluor® 488 Conjugation Kit (Fast) - Lightning-Link®

Immunocytochemistry - Alexa Fluor® 488 Conjugation Kit (Fast) - Lightning-Link® (AB236553)

  • 5
  • 5
Primary Antibodies

AB208670

Anti-Myeloperoxidase antibody [EPR20257]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Myeloperoxidase antibody [EPR20257] (AB208670)

  • 5
  • 7
Reagents, Controls & Accessories

AB176753

Phalloidin-iFluor 488 Reagent

Immunocytochemistry/ Immunofluorescence - Phalloidin-iFluor 488 Reagent (AB176753)

  • 5
  • 14
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "<p>Use 2 μg/250000 cells.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
Constituents: PBS, 0.1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Proteinase 3 (PR3) also known as PRTN3 is a serine protease with a mass of approximately 29 kDa. It belongs to the human neutrophil elastase (HNE) family and is mainly expressed in neutrophils. Within these immune cells PR3 localizes to azurophilic granules where it participates in early immune responses. The proteolytic activity of PR3 involves cleaving peptide bonds in target proteins contributing to the processing and degradation of various proteins important for immune function.
Biological function summary

Proteinase 3 serves multiple roles including modulating inflammation and immune responses. PR3 functions as part of a complex with azurophilic granules aiding in microbial defense mechanisms. In addition the protease regulates cytokine activation and deactivation which in turn influences cell signaling related to inflammation. Its enzymatic action ensures that PR3 can manage inflammatory processes by breaking down extracellular matrix components thereby allowing white blood cells to access infection sites.

Pathways

Proteinase 3 plays an important role within the serine protease and inflammatory pathways. It interacts with other proteins such as neutrophil elastase with which it shares a pathway to modulate immune responses. PR3 also partners with cathepsin G contributing to processes such as pathogen clearance and tissue remodeling providing a coordinated response during infection and injury. These interactions show PR3's involvement in regulating the balance between inflammation and tissue repair.

PR3 is notably associated with Wegener's granulomatosis also known as granulomatosis with polyangiitis. This autoimmune condition results in systemic vasculitis where anti-proteinase 3 antibodies notably characterize the disease. Additionally PR3 plays a part in chronic obstructive pulmonary disease (COPD) where its proteolytic activity contributes to tissue damage in the lungs. In both conditions PR3 interplays with related proteins like myeloperoxidase further demonstrating its importance in processes leading to these disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed : 2033050, PubMed : 28240246, PubMed : 3198760). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed : 23202369). Plays a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed : 22266279). Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation (PubMed : 36302784).
See full target information PRTN3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine reports 24: PubMed34296287

2021

Effect of intestinal microbiota imbalance associated with chronic hepatitis B virus infection on the expression of microRNA‑192 and GLP‑1.

Applications

Unspecified application

Species

Unspecified reactive species

Yinghui Liu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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