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AB60954

Anti-Progesterone Receptor (phospho S400) antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal Progesterone Receptor phospho S400 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PGR pS400.

대체 명칭 보기

NR3C3, PGR, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3

1 이미지
Western blot - Anti-Progesterone Receptor (phospho S400) antibody (AB60954)
  • WB

Unknown

Western blot - Anti-Progesterone Receptor (phospho S400) antibody (AB60954)

All lanes:

Western blot - Anti-Progesterone Receptor (phospho S400) antibody (ab60954) at 1/500 dilution

Lane 1:

293 cell extracts treated with heat shock

Lane 2:

293 cell extracts treated with heat shock with immunising peptide

Predicted band size: 98 kDa

Observed band size: 99 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PGR pS400. The exact immunogen used to generate this antibody is proprietary information.

P06401

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대체품

Primary Antibodies

AB101688

Anti-Progesterone Receptor antibody [SP42]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody [SP42] (AB101688)

  • 5
  • 2
Primary Antibodies

AB32085

Anti-Progesterone Receptor antibody [YR85]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody [YR85] (AB32085)

  • 4
  • 5
Primary Antibodies

AB206926

Anti-Progesterone Receptor antibody [YR85] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody [YR85] - BSA and Azide free (AB206926)

  • 0
  • 0
Primary Antibodies

AB75857

Anti-Progesterone Receptor (phospho S190) antibody [EP1516Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor (phospho S190) antibody [EP1516Y] (AB75857)

  • 0
  • 0

보완 제품

Primary Antibodies

AB32063

Anti-Estrogen Receptor alpha antibody [E115] - ChIP Grade

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|Advanced Validation|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Receptor alpha antibody [E115] - ChIP Grade (AB32063)

  • 4
  • 21
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB134182

Anti-ErbB2 / HER2 antibody [EP1045Y]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB2 / HER2 antibody [EP1045Y] (AB134182)

  • 4
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab60954 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The progesterone receptor (PR) also known as NR3C3 is a nuclear receptor that functions as a transcription factor in response to the hormone progesterone. This receptor has a mass of approximately 99 kDa and is expressed in tissues such as the reproductive organs including the uterus ovaries and mammary glands. It is also found in non-reproductive tissues like the brain and bone. The receptor has two main isoforms PR-A and PR-B which differ slightly in structure but have unique biological roles.
Biological function summary

The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.

Pathways

Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.

The progesterone receptor associates with breast cancer and endometriosis. Aberrant expression or mutations in PR can contribute to the development and progression of breast cancer often linked with the estrogen receptor's influence. In endometriosis PR's altered functionality affects cellular response to progesterone contributing to tissue growth outside the uterus. These conditions also involve interactions with proteins like BRCA1 in breast cancer highlighting how PR connects to broader cellular and pathological networks.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor.. Isoform A. Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.. Isoform B. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.. Isoform 4. Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
See full target information PGR pS400
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

OncoTargets and therapy 14:3757-3768 PubMed34168461

2021

Progesterone Receptor Together with PKCα Expression as Prognostic Factors for Astrocytomas Malignancy.

Applications

Unspecified application

Species

Unspecified reactive species

Denisse Arcos-Montoya,Talia Wegman-Ostrosky,Sonia Mejía-Pérez,Marisol De la Fuente-Granada,Ignacio Camacho-Arroyo,Alejandro García-Carrancá,Marco A Velasco-Velázquez,Joaquín Manjarrez-Marmolejo,Aliesha González-Arenas

Cells 10: PubMed33916643

2021

LPA Receptor Promotes Progesterone Receptor Phosphorylation through PKCα in Human Glioblastoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Anahi Valdés-Rives,Denisse Arcos-Montoya,Marisol de la Fuente-Granada,Carmen J Zamora-Sánchez,Luis Enrique Arias-Romero,Olga Villamar-Cruz,Ignacio Camacho-Arroyo,Sonia M Pérez-Tapia,Aliesha González-Arenas

Endocrinology 156:1010-22 PubMed25514083

2014

PKCα and PKCδ activation regulates transcriptional activity and degradation of progesterone receptor in human astrocytoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Aliesha González-Arenas,Miguel Ángel Peña-Ortiz,Valeria Hansberg-Pastor,Brenda Marquina-Sánchez,Noemi Baranda-Ávila,Karen Nava-Castro,Alejandro Cabrera-Wrooman,Jesús González-Jorge,Ignacio Camacho-Arroyo
제품이 사용된 논문 모두 보기
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Product promise

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