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AB17780

Anti-Properdin/PFC antibody [10C5]

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(2 제품이 사용된 논문 )

Mouse Monoclonal Properdin/PFC antibody. Suitable for ELISA, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human CFP.

대체 명칭 보기

PFC, CFP, Properdin, Complement factor P

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

10C5

Isotype

IgG1

Light chain 타입

kappa

Carrier free

No

Reacts with

Human

Applications

WB, ELISA

applications

Immunogen

Native Full Length Protein corresponding to Human CFP.

P27918

Specificity

To be determined.

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대체품

Proteins & Peptides

AB180316

Recombinant Human Properdin/PFC protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human Properdin/PFC protein (denatured) (His tag N-Terminus) (AB180316)

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  • 0
Primary Antibodies

AB58984

Anti-Properdin/PFC antibody [10-18]

  • 0
  • 0
Primary Antibodies

AB252531

Anti-Properdin/PFC antibody [3A3E1]

Recombinant|Trial Size

Flow Cytometry (Intracellular) - Anti-Properdin/PFC antibody [3A3E1] (AB252531)

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Primary Antibodies

AB254275

Anti-Properdin/PFC antibody [3A3E1] - BSA and Azide free

Recombinant

Flow Cytometry (Intracellular) - Anti-Properdin/PFC antibody [3A3E1] - BSA and Azide free (AB254275)

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보완 제품

Assay Kits

AB316252

Human Properdin/PFC ELISA Kit

SimpleStep|Recombinant

Sandwich ELISA - Human Properdin/PFC ELISA Kit (AB316252)

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Primary Antibodies

AB11878

Anti-C5a / C5a des Arg antibody [2952]

  • 4
  • 1
Primary Antibodies

AB52244

Anti-Factor I/CFI antibody [3D6] - BSA and Azide free

  • 0
  • 0
Primary Antibodies

AB17452

Anti-C2 antibody [6E3]

  • 0
  • 0
Primary Antibodies

AB190834

Anti-MBL1+MBL2 antibody [EPR18381-156]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MBL1+MBL2 antibody [EPR18381-156] (AB190834)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Properdin also known as factor P or complement factor P plays an essential role in the immune system. It is a serum protein with a molecular mass of approximately 53 kDa. Properdin is most commonly expressed in monocytes neutrophils and activated macrophages. It serves as a positive regulator in the alternative pathway of the complement system providing stability to the complement convertase complexes C3bBb and C3bBbC3b.
Biological function summary

Properdin enhances the activity of the complement system by stabilizing the C3 and C5 convertase enzyme complexes. These complexes are critical in the amplification of the complement cascade leading to pathogen opsonization and lysis. Properdin does not form part of a complex alone but helps existing complement complexes carry out their functions more effectively. By supporting these complexes properdin contributes to immune surveillance and the host's response to microbial invaders.

Pathways

Properdin operates within the alternative complement pathway and plays a pivotal role in immune defense. It interacts with other components such as C3 and C5 contributing to the pathway's ability to clear pathogens and damaged cells. Properdin's activity also indirectly influences other related proteins in the complement system supporting a coordinated immune response that involves factors beyond the alternative pathway itself.

Properdin deficiencies or dysregulations can lead to increased susceptibility to infections particularly by Neisseria species accounting for recurrent meningococcal disease. Additionally abnormal properdin function links to autoimmune conditions such as systemic lupus erythematosus. This connection is due to its relationship with various complement factors such as C3 which are vital for maintaining immune homeostasis.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

A positive regulator of the alternate pathway (AP) of complement (PubMed : 16301317, PubMed : 20382442, PubMed : 28264884, PubMed : 9748277). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed : 16301317, PubMed : 20382442, PubMed : 28264884, PubMed : 9748277). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed : 31507604).
See full target information CFP
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell chemical biology 28:14-25.e9 PubMed33176158

2020

Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade.

Applications

Unspecified application

Species

Unspecified reactive species

A Katherine Hatstat,Hannah D Ahrendt,Matthew W Foster,Leland Mayne,M Arthur Moseley,S Walter Englander,Dewey G McCafferty

Oncology reports 39:2279-2287 PubMed29498404

2018

Deleted in malignant brain tumor 1 is a novel prognostic marker in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Heae Surng Park,Byung Chang Kim,Hyun Yang Yeo,Kyung-Hee Kim,Byong Chul Yoo,Ji Won Park,Hee Jin Chang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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