AB217925

Anti-Prostaglandin E Receptor EP1/PTGER1 antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal Prostaglandin E Receptor EP1/PTGER1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human PTGER1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

Prostaglandin E2 receptor EP1 subtype, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostanoid EP1 receptor, PTGER1

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue labeling Prostaglandin E Receptor EP1/PTGER1 with ab217925 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse kidney tissue labeling Prostaglandin E Receptor EP1/PTGER1 with ab217925 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Supplier Data

Western blot - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

All lanes:

Western blot - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (ab217925) at 1/200 dilution

All lanes:

mouse kidney lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 42 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human PTGER1 aa 50-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P34995

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Prostaglandin E Receptor EP1 also known as PTGER1 is a protein encoded by the PTGER1 gene. It belongs to the G-protein-coupled receptor family and is recognized for its role in binding prostaglandin E2 (PGE2). PTGER1 is a transmembrane protein which traverses the cell membrane multiple times. This receptor has a molecular mass of approximately 42 kDa. It is expressed in various tissues including the kidney lung and stomach which suggests its role in different physiological processes.

Biological function summary

PTGER1 plays a significant role in modulating vascular smooth muscle function. It does not operate as a part of a larger protein complex but rather works independently to initiate cellular responses upon binding with PGE2. The activation of PTGER1 influences various physiological processes such as inflammation pain perception and smooth muscle contraction. It achieves this by enabling the intracellular signaling that contributes to these bodily responses.

Pathways

PTGER1 functions in essential signaling cascades particularly the prostaglandin signaling pathway. Also it interfaces with the G-protein coupled receptor signaling pathway which involves proteins such as Gq/11. PTGER1 activation can both amplify and regulate the downstream signaling events linking the receptor to processes involved in inflammation and pain response.

PTGER1's regulation of inflammation and smooth muscle contraction connects it to conditions such as hypertension and gastric ulcers. Altered expression or function of PTGER1 may contribute to these diseases by affecting blood pressure regulation and gastric mucosal integrity. In context of gastric ulcers PTGER1 engages with cyclooxygenase-2 (COX-2) a known mediator of inflammation and ulcerogenesis suggesting a potential area for therapeutic intervention by targeting this receptor.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

See full target information PTGER1

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 13: PubMed40028769

2025

The Kv2.2 channel mediates the inhibition of prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chengfang Pan,Ying Liu,Liangya Wang,Wen-Yong Fan,Yunzhi Ni,Xuefeng Zhang,Di Wu,Chenyang Li,Jin Li,Zhaoyang Li,Rui Liu,Changlong Hu

Archives of dermatological research 316:312 PubMed38822924

2024

The effect of selinexor on prostaglandin synthesis in virus-positive Merkel cell carcinoma cell lines.

Applications

Unspecified application

Species

Unspecified reactive species

Deepika Narayanan,Brooke Bartley,Jennifer Landes,Stephen A Moore,Veda Kulkarni,Qin He,Rebecca Simonette,Hung Q Doan,Peter L Rady,Stephen K Tyring

Journal of cancer research and clinical oncology 149:5369-5376 PubMed36436093

2022

Prostaglandin E2 receptor EP1 expression in vulvar cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Buchholz,Aurelia Vattai,Sophie Fürst,Theresa Vilsmaier,Alaleh Zati Zehni,Alexander Steger,Christina Kuhn,Elisa Schmoeckel,Christian Dannecker,Sven Mahner,Udo Jeschke,Helene H Heidegger

Parasites & vectors 14:279 PubMed34034779

2021

Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Chen,Xiaofang Ji,Manni Wang,Xiaoyan Liao,Cuiying Liang,Juanjuan Tang,Zhencheng Wen,Ferrandon Dominique,Zi Li

Cell death & disease 11:221 PubMed32251289

2020

mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yiqing Li,Jiaoting Chen,Wenjuan Yang,Hongyun Liu,Jieyu Wang,Jie Xiao,Shuangfeng Xie,Liping Ma,Danian Nie

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prostaglandin E Receptor EP1/PTGER1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

Western blot - Anti-Prostaglandin E Receptor EP1/PTGER1 antibody (AB217925)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise