AB124419

Anti-Prostaglandin E Receptor EP2/PTGER2 antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal Prostaglandin E Receptor EP2/PTGER2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Prostaglandin E2 receptor EP2 subtype.

대체 명칭 보기

Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor, PTGER2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody (AB124419)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody (AB124419)

Staining of Prostaglandin E Receptor EP2/PTGER2 in Paraffin-embedded Human Uterus, Myometrium tissue by Immunohistochemistry using ab124419 at a concentration of 5 μg/ml.

Unknown

Western blot - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody (AB124419)

All lanes:

Western blot - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody (ab124419) at 1/500 dilution

Lane 1:

Mouse liver cell extract

Lane 2:

Mouse liver cell extract with synthesized peptide

Predicted band size: 40 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Prostaglandin E2 receptor EP2 subtype. The exact immunogen used to generate this antibody is proprietary information.

P43116

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Prostaglandin E Receptor EP2 also known as PTGER2 or EP2 receptor is a G-protein coupled receptor with a molecular mass of approximately 53 kDa. This receptor primarily binds prostaglandin E2 (PGE2) mediating various cellular responses. EP2 receptor is expressed in tissues such as the brain kidneys lungs and immune cells. Its activation leads to the stimulation of adenylyl cyclase increasing levels of cyclic AMP (cAMP) within the cell.

Biological function summary

The EP2 receptor plays a role in vasodilation immune modulation and regulation of pain and inflammation. It does not act as part of a large protein complex but rather exerts its effects individually through its coupling with G-proteins. EP2 receptor stimulation results in smooth muscle relaxation and has implications in neuroinflammation and renal function.

Pathways

The EP2 receptor is involved in the prostaglandin signaling pathway and contributes to the inflammatory response pathway. It shares a connection with other receptors such as EP1 EP3 and EP4 which also bind PGE2 but induce different cellular responses. These pathways integrate signals that modulate processes like inflammation and immune responses highlighting EP2's role in maintaining physiological balance.

EP2 receptor activity is associated with conditions like asthma and Alzheimer's disease. In asthma the receptor's activity may influence airway hyperresponsiveness through its effects on smooth muscle and immune cells. In Alzheimer's EP2 receptor-related pathways may contribute to neuroinflammation which is linked with disease progression. Connections with proteins like COX-2 can be noted in these disorders as COX-2-dependent prostaglandin synthesis directly affects EP2 receptor signaling and subsequent cellular outcomes.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

See full target information Prostaglandin E2 receptor EP2 subtype

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Naunyn-Schmiedeberg's archives of pharmacology : PubMed40372476

2025

Therapeutic effect of bismuth subsalicylate in a propionic acid-induced autism model.

Applications

Unspecified application

Species

Unspecified reactive species

Kubilay Doğan Kılıç,Burak Çakar,Yiğit Uyanıkgil,Lora Koenhemsi,Berzah Güneş,Ebru Eroğlu,Oytun Erbaş

Acta neuropathologica 149:39 PubMed40299057

2025

Spatial mapping of the AA-PGE-EP axis in multiple sclerosis lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Cathrin E Hansen,Julia Konings,Gabor Toth,Serhii Chornyi,Manon Karsten,Bert van Het Hof,Susanne M A van der Pol,Stephanie D Beekhuis-Hoekstra,Nine Kok,Wing Ka Fung,Naomi S Dijksman,Wia Baron,Maarten E Witte,Ingela Lanekoff,Helga E de Vries,Gijs Kooij

Cell reports 36:109674 PubMed34496236

2021

Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche.

Applications

Unspecified application

Species

Unspecified reactive species

Xi He,Sarah E Smith,Shiyuan Chen,Hua Li,Di Wu,Paloma I Meneses-Giles,Yongfu Wang,Mark Hembree,Kexi Yi,Xia Zhao,Fengli Guo,Jay R Unruh,Lucinda E Maddera,Zulin Yu,Allison Scott,Anoja Perera,Yan Wang,Chongbei Zhao,KyeongMin Bae,Andrew Box,Jeffrey S Haug,Fang Tao,Deqing Hu,Darrick M Hansen,Pengxu Qian,Subhrajit Saha,Dan Dixon,Shrikant Anant,Da Zhang,Edward H Lin,Weijing Sun,Leanne M Wiedemann,Linheng Li

Contemporary oncology (Poznan, Poland) 19:113-9 PubMed26034388

2015

Expression of prostaglandin E2 prostanoid receptor EP2 and interleukin-1β in laryngeal carcinoma - preliminary study.

Applications

IHC-P

Species

Human

Marcin Mochocki,Piotr Morawski,Renata Kopta,Ewa Brzezińska-Błaszczyk,Olga Stasikowska,Iwona Lewy-Trenda,Katarzyna Starska

The Journal of biological chemistry 287:25434-9 PubMed22654101

2012

Prostanoid receptor 2 signaling protects T helper 2 cells from BALB/c mice against activation-induced cell death.

Applications

Species

Mouse

Vandana Kaul,Luc Van Kaer,Gobardhan Das,Jyoti Das

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Prostaglandin E Receptor EP2/PTGER2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody (AB124419)

Western blot - Anti-Prostaglandin E Receptor EP2/PTGER2 antibody (AB124419)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise