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AB196677

Anti-Prosurfactant Protein C antibody

1

(1 리뷰)

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(3 제품이 사용된 논문 )

Rabbit Polyclonal Prosurfactant Protein C antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SFTPC.

대체 명칭 보기

SFTP2, SFTPC, Surfactant protein C, SP-C, Pulmonary surfactant-associated protein C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Prosurfactant Protein C antibody (AB196677)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Prosurfactant Protein C antibody (AB196677)

Immunofluorescent analysis of U2OS cells labeling SFTPC with ab196677 at 1/50 dilution. Lower image with DAPI for nuclear staining.

Western blot - Anti-Prosurfactant Protein C antibody (AB196677)
  • WB

Supplier Data

Western blot - Anti-Prosurfactant Protein C antibody (AB196677)

All lanes:

Western blot - Anti-Prosurfactant Protein C antibody (ab196677) at 1/500 dilution

Lane 1:

Jurkat cell extract

Lane 2:

U937 cell extract

Lane 3:

Raji cell extract

Predicted band size: 21 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SFTPC.

P11686

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대체품

Primary Antibodies

AB167608

Anti-Prosurfactant Protein C antibody

  • 0
  • 0
Primary Antibodies

AB90716

Anti-Prosurfactant Protein C antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Prosurfactant Protein C antibody (AB90716)

  • 4
  • 12

보완 제품

Assay Kits

AB252366

Mouse SFTPC ELISA Kit

Recombinant|SimpleStep

ELISA - Mouse SFTPC ELISA Kit (AB252366)

  • 0
  • 0
Primary Antibodies

AB52635

Anti-Cytokeratin 5 antibody [EP1601Y] - Cytoskeleton Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 5 antibody [EP1601Y] - Cytoskeleton Marker (AB52635)

  • 5
  • 11
Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

  • 5
  • 8
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB76013

Anti-TTF1/Nkx2-1 antibody [EP1584Y]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTF1/Nkx2-1 antibody [EP1584Y] (AB76013)

  • 5
  • 18
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Prosurfactant Protein C (Pro-SP-C) often referred to as SPC or by its abbreviated form SP-C is a hydrophobic peptide critical for lung function. This protein has a mass of approximately 21 kDa and is expressed prominently in the alveolar type II cells of the lung tissue. Beyond its full-length variant various pro forms such as proSP-C are studied for their roles during protein maturation and trafficking. These pro forms are essential for producing the mature functional SP-C a critical component of lung surfactant which reduces surface tension in alveoli and prevents lung collapse.
Biological function summary

In surfactant homeostasis Prosurfactant Protein C associates with surfactant protein complexes where it interacts with phospholipids like phosphatidylcholine to stabilize the alveolar structures. As part of this complex it aids in reducing surface tension at the air-liquid interface in the alveoli and contributes to the host defense system by fostering pathogen clearance and modulating inflammation. The intricate processing of Pro-SP-C into its mature form involves fucosylation and other post-translational modifications which are key for functional surfactant activity.

Pathways

The role of Prosurfactant Protein C is integral to the surfactant metabolism pathway affecting lung function and homeostasis. This pathway is important for proper respiratory mechanics and is closely linked to other surfactant proteins like SP-B and SP-D. These proteins work together within the lipid-protein matrix of the surfactant to ensure proper alveolar deflation and reinflation during respiration. Disruption within these pathways can have significant impact on lung health and respiratory physiology.

Mutations or dysfunctions in Prosurfactant Protein C are linked to interstitial lung diseases including pulmonary alveolar proteinosis and idiopathic pulmonary fibrosis. These conditions often result from misfolded proteins or improper surfactant metabolism leading to compromised lung function. Connections with disorders like these highlight interactions between Prosurfactant Protein C and C-reactive protein uncovering underlying inflammatory processes. Therapy and research often target these protein interactions and modifications as understanding them holds potential for strategic intervention in surfactant-related pathologies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
See full target information SFTPC
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

JCI insight 7: PubMed35993367

2022

Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Agata Radwanska,Christopher Travis Cottage,Antonio Piras,Catherine Overed-Sayer,Carina Sihlbom,Ramachandramouli Budida,Catherine Wrench,Jane Connor,Susan Monkley,Petra Hazon,Holger Schluter,Matthew J Thomas,Cory M Hogaboam,Lynne A Murray

Annals of translational medicine 9:563 PubMed33987261

2021

Nogo-B promotes epithelial-mesenchymal transition in lung fibrosis via PERK branch of the endoplasmic reticulum stress pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Zhu,Meng Yang,Xue-Hui Li,Wu-Jian Xu,Wei Gao,Yu-Han Chen,Jian-Dong Li,Qiang Li

Nature communications 10:1985 PubMed31064987

2019

Regeneration of severely damaged lungs using an interventional cross-circulation platform.

Applications

Unspecified application

Species

Unspecified reactive species

Brandon A Guenthart,John D O'Neill,Jinho Kim,Dawn Queen,Scott Chicotka,Kenmond Fung,Michael Simpson,Rachel Donocoff,Michael Salna,Charles C Marboe,Katherine Cunningham,Susan P Halligan,Holly M Wobma,Ahmed E Hozain,Alexander Romanov,Gordana Vunjak-Novakovic,Matthew Bacchetta
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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